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CC BY-NC-ND 4.0 · Journal of Health and Allied Sciences NU 2018; 08(01): 11-14
DOI: 10.1055/s-0040-1708738
Original Article

Comparison of Inflammatory Markers like C - Reactive Protein, Total Leukocyte Count and Erythrocyte Sedimentation Rate in Type II Diabetes Mellitus

Aditya Mungamuri
1   UG Student, Dept. of Pathology, K S Hegde Medical Academy, Mangalore - 575018
,
Sunil Kumar Y.
2   Additional Professor, Dept. of Pathology, K S Hegde Medical Academy, Mangalore - 575018
,
Suchetha Kumari N.
3   Professor, Dept. of Biochemistry, K S Hegde Medical Academy, Mangalore - 575018
,
Ullal Harshini Devi
4   Central Research Laboratory, K S Hegde Medical Academy, Mangalore - 575018
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Abstract

Background: Diabetes Mellitus (DM) has become an epidemic in the 21st century where India leads the world with largest number of patients. There is increasing evidence that inflammation is closely involved in the pathogenesis of type 2 diabetes and associated complications such as dyslipidaemia and atherosclerosis. Many previous studies indicate inflammatory markers like CRP, IL-6, IL-8, TNF-alpha, fibrinogen, total sialic acid, ceruloplasmin and total leucocyte count (TLC) are raised in Type II Diabetes Mellitus. However, not many studies have done association of ESR and TLC in DM.

Aims: In the present study inflammatory markers like CRP, total leukocyte count and ESR were compared in diabetic and non-diabetic patients.

Materials and Methods: 5mL of venous blood was taken from the study subjects.CRP, TLC and ESR was estimated.

Results: There was a significant rise in the CRP, TLC and ESR values seen in patients diagnosed with type II diabetes mellitus when compared to normal individuals. All three parameters (CRP, TLC, and ESR) were raised in a total of 7 cases (14%). 14 cases (28%) showed elevated levels of both CRP and ESR. A significant 8 cases (16%) showed elevation of CRP alone. There was a rise of ESR alone in 5 cases (10%).

Conclusion: CRP, TLC and ESR are elevated in diabetic patients in comparison to normal individuals. These increase the risk of diabetic related complications like atherosclerosis and dyslipaedemia. Hence, anti-inflammatory drugs in combination with antidiabetic treatment can delay these complications.

Keywords

Diabetes mellitus - Inflammatory markers - C-Reactive Protein, - Total Leucocyte Count - Erythrocyte Sedimentation Rate


Publication History

Received: 22 July 2017

Accepted: 02 February 2018

Article published online:
20 April 2020

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  • References

  • 1 World Health Organisation. Definition, Diagnosis and Classification of Diabetes Mellitus and its complications. Report of a WHO Consultation. Geneva: World Health Organisation, 1999.
  • 2 Wild S, Roglic G, Green A, Sicree R, King H. Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030. Diabetes care 2004;27:1047-53
  • 3 Sicree R, Shaw J, Zimmet P. Diabetes and impaired glucose tolerance. rd In: Gan D, editor. Diabetes Atlas. International Diabetes Federation. 3 ed. Belgium: International Diabetes Federation; 2006 p. 15-103.
  • 4 NEEL JV. Diabetes mellitus: a “thrifty” genotype rendered detrimental by “progress”? Am J Hum Genet 1962; 14:353-62.
  • 5 Vinay Kumar, Abdul K Abbas, Jon C Aster. Robins and Cotran th Pathological Basis of Disease. 9 edition: Elsevier Inc; 2015.
  • 6 Singh, Sunitha. The genetics of Type II Diabetes mellitus: a review. J Sci res 2011; 35-4
  • 7 Wang X, Bao W, Liu J, OuYang Y, Wang D, Rong S et al. inflammatory Markers and Risk Type II Diabetes: A systemic review and metaanalysis. Diabetes care 2012; 36:166-75
  • 8 Pradhan A. C-Reactive Protein, IL-6, and risk of developimg Type II Diabetes Mellitus. JAMA 2001; 286:327.
  • 9 Hu FB, Meigs JB, Li TY, Rifai N, Manson JE. Inflammatory markers and risk of developing Type II Diabetes in women. Diabetes 2004; 53:693-700.
  • 10 Twig G, Afek A, Shamiss A, Deranze E, Tzur D, Gordon B et al. White Blood Cells Count And Incidence of Type 2 Diabetes in young men. Diabetes care. 2012; 36:276-282.
  • 11 Mugabo Y, Li L, Reiner G. The Connection Between C-Reactive Protein and Diabetic vasculopathy. Focus on preclinical findings. Current diabetes reviews. 2010; 6(1):27-34.
  • 12 Ridker P. Clinical Application of CRP for Cardiovascular Disease detection and prevention. Circulation. 2003; 107(3):363-369.
  • 13 AN Elias, E Domurat. Erythrocyte sedimentation rate in diabetic patients: relationship to glycosylated haemoglobin and serum proteins. J Med. 1989; 20(3-4):297-302.
  • 14 Chung F, Tsai J, Chang D, Shin S, Lee Y. Peripheral Total and Differential Leukocyte Count in Diabetic Neuropathy: The relationship of plasma leptin to leucocytosis. Diabetes care. 2005; 28(7):1710-1717.