Am J Perinatol 2021; 38(S 01): e182-e186
DOI: 10.1055/s-0040-1708884
Original Article

Perinatal Risk Factors Influencing Neonatal Hypoxic Ischemic Encephalopathy in Southern China: A Case–Control Study

Junrong Wang
1  Department of Laboratory Medicine, Wenling Maternal and Child Health Care Hospital, Zhejiang Province, China
,
Enfu Tao
2  Department of Pediatrics, Wenling Maternal and Child Health Care Hospital, Zhejiang Province, China
,
Miaojun Mo
2  Department of Pediatrics, Wenling Maternal and Child Health Care Hospital, Zhejiang Province, China
,
Weimin Ding
3  Department of Obstetrics and Gynecology, Wenling Maternal and Child Health Care Hospital, Zhejiang Province, China
,
Junhui Yuan
2  Department of Pediatrics, Wenling Maternal and Child Health Care Hospital, Zhejiang Province, China
,
Min Wang
4  Department of Laboratory Medicine, Taizhou Women's and Children's Hospital, Zhejiang Province, China
,
2  Department of Pediatrics, Wenling Maternal and Child Health Care Hospital, Zhejiang Province, China
,
Haixiao Zheng
4  Department of Laboratory Medicine, Taizhou Women's and Children's Hospital, Zhejiang Province, China
› Author Affiliations
Funding This work was supported by the Science and Technology Foundation, Wenling, Zhejiang Province, China (W2016196).

Abstract

Objective In this study, our objective was to explore the relevant influencing factors of neonatal hypoxic-ischemic encephalopathy (HIE) in Southern China and provide scientific basis for improving the quality of life for neonates.

Study Design A retrospective analysis of 306 cases with HIE neonates who were admitted during April 2015 to October 2017 was conducted. A total of 306 non-HIE patients admitted to the same hospital during the same period were also included as controls. The basic clinical characteristics were analyzed, and the risk factors for HIE were assessed by logistic regression analysis.

Results Univariate analysis showed that the differences in medicals during pregnancy, placenta previa, fetal distress during labor, cesarean section, amniotic fluid contamination, abnormal labor stage, and Apgar showed significantly different in the case group and the control group (p < 0.05). The multivariate logistic regression analysis revealed that the placenta previa, medicals during pregnancy, fetal distress, abnormal labor stage, Apgar's score, amniotic fluid contamination, and cesarean section were independent risk factors for HIE.

Conclusion The placenta previa, medicals during pregnancy, fetal distress, and abnormal labor stage can increase the risk of HIE. Early detection, early diagnosis, and treatment might make great achievement in improving the life quality of HIE neonates.

Authors' Contributions

H.Z. and C.Z. supported in conception and intellectual input. J.W. and E.T. designed and carried out the performance of experimentation. M.M. drafted the manuscript. W.D., J.Y., and M.W. performed statistical analyses and data interpretation. All authors have read and approved the final manuscript.


These authors acted as the co-first authors.




Publication History

Received: 16 October 2019

Accepted: 19 February 2020

Publication Date:
27 March 2020 (online)

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