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Perinatal Risk Factors Influencing Neonatal Hypoxic Ischemic Encephalopathy in Southern China: A Case–Control StudyFunding This work was supported by the Science and Technology Foundation, Wenling, Zhejiang Province, China (W2016196).
Objective In this study, our objective was to explore the relevant influencing factors of neonatal hypoxic-ischemic encephalopathy (HIE) in Southern China and provide scientific basis for improving the quality of life for neonates.
Study Design A retrospective analysis of 306 cases with HIE neonates who were admitted during April 2015 to October 2017 was conducted. A total of 306 non-HIE patients admitted to the same hospital during the same period were also included as controls. The basic clinical characteristics were analyzed, and the risk factors for HIE were assessed by logistic regression analysis.
Results Univariate analysis showed that the differences in medicals during pregnancy, placenta previa, fetal distress during labor, cesarean section, amniotic fluid contamination, abnormal labor stage, and Apgar showed significantly different in the case group and the control group (p < 0.05). The multivariate logistic regression analysis revealed that the placenta previa, medicals during pregnancy, fetal distress, abnormal labor stage, Apgar's score, amniotic fluid contamination, and cesarean section were independent risk factors for HIE.
Conclusion The placenta previa, medicals during pregnancy, fetal distress, and abnormal labor stage can increase the risk of HIE. Early detection, early diagnosis, and treatment might make great achievement in improving the life quality of HIE neonates.
H.Z. and C.Z. supported in conception and intellectual input. J.W. and E.T. designed and carried out the performance of experimentation. M.M. drafted the manuscript. W.D., J.Y., and M.W. performed statistical analyses and data interpretation. All authors have read and approved the final manuscript.
∗ These authors acted as the co-first authors.
Received: 16 October 2019
Accepted: 19 February 2020
27 March 2020 (online)
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