Development of Myocardial Infarction in a 12-Year-Old Female after the Use of Inhaled SalbutamolFunding None.
Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) accounts for 0.023% of all cases reported in pediatric patients. According to literature, only a handful of ALCAPA patients are able to reach adulthood. Clinical manifestations of ALCAPA range from fatigue during exercise to sudden death in adulthood. Herein, we described a 12-year-old symptomatic patient with ALCAPA who had severe chest pain after using salbutamol treatment for presumed asthma. ALCAPA is one of the curable versions of myocardial ischemia and infarction in childhood. Due to clinical findings in conjunction with electrocardiogram and echocardiography, a computed tomography scan with coronary angiography was performed and the diagnosis of ALCAPA was confirmed. We presented this case because ALCAPA-related myocardial ischemia and infarction in children are rare with only sporadic cases reported. This case illustrated the need for close monitoring and surgery as the best treatment for ALCAPA associated with myocardial infarction.
All authors participated in creating content for the manuscript, editing, and providing final approval for submission.
This article does not contain any studies with human participants or animals performed by any of the authors. Institutional Review Board approval was not required for this case report. Permission was granted by the parents and patient to publish the case report.
Received: 25 January 2020
Accepted: 01 March 2020
05 May 2020 (online)
© 2020. Thieme. All rights reserved.
Georg Thieme Verlag KG
Stuttgart · New York
- 1 Frommelt PC, Frommelt MA. Congenital coronary artery anomalies. Pediatr Clin North Am 2004; 51 (05) 1273-1288
- 2 Chang RR, Allada V. Electrocardiographic and echocardiographic features that distinguish anomalous origin of the left coronary artery from pulmonary artery from idiopathic dilated cardiomyopathy. Pediatr Cardiol 2001; 22 (01) 3-10
- 3 Dodge-Khatami A, Mavroudis C, Backer CL. Anomalous origin of the left coronary artery from the pulmonary artery: collective review of surgical therapy. Ann Thorac Surg 2002; 74 (03) 946-955
- 4 Maron BJ. Triggers for sudden cardiac death in the athlete. Cardiol Clin 1996; 14 (02) 195-210
- 5 Frapier JM, Leclercq F, Bodino M, Chaptal PA. Malignant ventricular arrhythmias revealing anomalous origin of the left coronary artery from the pulmonary artery in two adults. Eur J Cardiothorac Surg 1999; 15 (04) 539-541
- 6 Wesselhoeft H, Fawcett JS, Johnson AL. Anomalous origin of the left coronary artery from the pulmonary trunk. Its clinical spectrum, pathology, and pathophysiology, based on a review of 140 cases with seven further cases. Circulation 1968; 38 (02) 403-425
- 7 Robinson PJ, Sullivan ID, Kumpeng V, Anderson RH, Macartney FJ. Anomalous origin of the left coronary artery from the pulmonary trunk. Potential for false negative diagnosis with cross sectional echocardiography. Br Heart J 1984; 52 (03) 272-277
- 8 Au DH, Curtis JR, Every NR, McDonell MB, Fihn SD. Association between inhaled beta-agonists and the risk of unstable angina and myocardial infarction. Chest 2002; 121 (03) 846-851
- 9 Au DH, Lemaitre RN, Curtis JR, Smith NL, Psaty BM. The risk of myocardial infarction associated with inhaled beta-adrenoceptor agonists. Am J Respir Crit Care Med 2000; 161 (3 Pt 1): 827-830
- 10 Lemaitre RN, Siscovick DS, Psaty BM. et al. Inhaled beta-2 adrenergic receptor agonists and primary cardiac arrest. Am J Med 2002; 113 (09) 711-716
- 11 Salpeter SR. Cardiovascular safety of beta(2)-adrenoceptor agonist use in patients with obstructive airway disease: a systematic review. Drugs Aging 2004; 21 (06) 405-414
- 12 Vouhé PR, Baillot-Vernant F, Trinquet F. et al. Anomalous left coronary artery from the pulmonary artery in infants. Which operation? When?. J Thorac Cardiovasc Surg 1987; 94 (02) 192-199