Synovial Fluid Mesenchymal Stem Cells for Knee Arthritis and Cartilage Defects: A Review of the Literature

William Fang; ZhiTao Sun; Xiao Chen; Bo Han; C. Thomas Vangsness Jr.

doi:10.1055/s-0040-1710366

The Journal of Knee Surgery, Inhaltsverzeichnis

J Knee Surg 2021; 34(13): 1476-1485
DOI: 10.1055/s-0040-1710366

Original Article

Synovial Fluid Mesenchymal Stem Cells for Knee Arthritis and Cartilage Defects: A Review of the Literature

Autor*innen

William Fang

¹Department of Orthopaedic Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California
ZhiTao Sun

²Department of Medicine, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, Guangzhou, China
Xiao Chen

¹Department of Orthopaedic Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California
Bo Han

³Department of Surgery, USC Keck School of Medicine, Los Angeles, California
C. Thomas Vangsness Jr.

¹Department of Orthopaedic Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California

Abstract

Mesenchymal stem cells (MSCs) are adult stem cells that have the ability to self-renew and differentiate into several cell lineages including adipocytes, chondrocytes, tenocytes, bones, and myoblasts. These properties make the cell a promising candidate for regenerative medicine applications, especially when dealing with sports injuries in the knee. MSCs can be isolated from almost every type of adult tissue. However, most of the current research focuses on MSCs derived from bone marrow, adipose, and placenta derived products. Synovial fluid-derived MSCs (SF-MSCs) are relatively overlooked but have demonstrated promising therapeutic properties including possessing higher chondrogenic proliferation capabilities than other types of MSCs. Interestingly, SF-MSC population has shown to increase exponentially in patients with joint injury or disease, pointing to a potential use as a biomarker or as a treatment of some orthopaedic disorders. In this review, we go over the current literature on synovial fluid-derived MSCs including the characterization, the animal studies, and discuss future perspectives.

Keywords

synovial fluid - mesenchymal stem cells - cartilage regeneration - osteoarthritis

Volltext

Referenzen

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