Am J Perinatol 2020; 37(08): 869-872
DOI: 10.1055/s-0040-1710541
Short Communication
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Neonatal Late Onset Infection with Severe Acute Respiratory Syndrome Coronavirus 2

1  Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
,
Simonetta Costa*
1  Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
,
Maurizio Sanguinetti
2  Dipartimento Scienze di laboratorio e infettivologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
,
Paola Cattani
2  Dipartimento Scienze di laboratorio e infettivologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
,
Brunella Posteraro
2  Dipartimento Scienze di laboratorio e infettivologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
,
Simona Marchetti
2  Dipartimento Scienze di laboratorio e infettivologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
,
Brigida Carducci
1  Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
,
Antonio Lanzone
1  Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
,
Enrica Tamburrini
2  Dipartimento Scienze di laboratorio e infettivologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
,
Giovanni Vento
1  Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
,
Piero Valentini
1  Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
› Author Affiliations
Further Information

Publication History

21 April 2020

21 April 2020

Publication Date:
02 May 2020 (online)

Abstract

Objective To date, no information on late-onset infection in newborns to mother with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contracted in pregnancy are available. This study aimed to evaluate postdischarge SARS-CoV-2 status of newborns to mothers with COVID-19 in pregnancy that, at birth, were negative to SARS-CoV-2.

Study Design This is an observational study of neonates born to mothers with coronavirus disease 2019 (COVID-19).

Results Seven pregnant women with documented SARS-CoV-2 infection have been evaluated in our institution. One woman had a spontaneous abortion at 8 weeks of gestational age, four women recovered and are still in follow-up, and two women delivered. Two newborns were enrolled in the study. At birth and 3 days of life, newborns were negative to SARS-CoV-2. At 2-week follow-up, one newborn tested positive although asymptomatic.

Conclusion Our findings highlight the importance of follow-up of newborns to mothers with COVID-19 in pregnancy, since they remain at risk of contracting the infection in the early period of life and long-term consequences are still unknown.

Key Points

  • Newborns to mothers with coronavirus disease 2019 (COVID-19) in pregnancy can acquire the infection later after birth.

  • Newborns to mothers with COVID-19 in pregnancy need a long-term follow-up, even if they tested negative at birth.

  • Specific guidelines for the long-term follow-up of newborns to mothers with COVID-19 in pregnancy are needed.

* These authors act as first authors.