Einfluss von Rauchen auf das Gesamtüberleben bei HPV-assoziierten Kopf-Hals-Karzinomen: Meta-Analyse.

Introduction Head and neck cancers makes around 4 % of all malignancy in Europe. The HPV positive Oropharyngeal cancer is associated with good prognosis compared to HPV negative. Therefore the p16 status as surrogate marker of HP is considered in the TNM classification 8^th edition. Smoking is associated with poor prognosis and is not considered in the TNM classification 8^th edition. According to our knowledge, there is no meta-analysis, that assessed the overall survival of HNSCC according to status of HPV/smoking combined. The aim of this study was to evaluate the impact of smoking on the overall survival in HPV associated head and neck cancer.

Methods We performed a meta-analysis to assess the overall survival of HNSCC using HPV and smoking. A literature review conducted in Pubmed using the search terms “HPV, Smoking and Head and neck cancer until November 2019.

Results A total of 8 out of 739 articles fulfilled our inclusion criteria, with total of 1596 patients. 77.6 % were male und 22.4 were female. Only 593 Patients were included in the meta-analysis. The prevalence of HPV+/smoking is 50.6 % and HPV+/non-smoking is 49.4 %. The meta-analysis shows a significantly improvement of the 5-year overall survival (OS) of HPV+/non-smoking compared to HPV+/smoking with relative risk of 0.49 95 % CI [0.36; 0.68].

Conclusion Smoking is a strong poor prognostic factor in the presence of HPV for the overall survival (OS).

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Publication History

Article published online:
10 June 2020