Rare entity of a congenital solid tumor in infancy: a case description

Introduction Congenital tumors in infants are a rarity. About 2 % of all pediatric malignancies occur in the neonatal period. According to the Brithish Paediatric Pathology Society, the prevalence of congenital neoplasia (benign and malignant) is between 1:12 500 and 17 300 live births.

Material and Methods A systematic literature research on PubMed with the keywords "agnogenic myeloid metaplasia and childhood" as well as a review of the case described below was carried out.

Results An almost two weeks old infant with a new formation of unclear dignity submandibular was presented in our clinic. Sonography showed a shallow limited echo poor inhomogeneous tumor in region IB on the right side. In the MRI neck an 18 x 17 x 15 mm malignome-suspicious tumor with contact to the submandibular gland was described. The indication for a tumor removal with submandibulectomy was given and performed without complications. Histologically an "agnogenic myeloid metaplasia in childhood" was diagnosed. This is a chronic myeloproliferative disease characterized by fibrosis of the bone marrow.

Conclusion Solid tumors in newborns are very rare and represent a surgical and therapeutic challenge due to the young age of the patient. Rare entities, as in the present case, should be considered in a differential diagnosis in pediatric patients.

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Publication History

Article published online:
10 June 2020