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Collagen Type I/III Matrix (Mucograft) for the plastic coverage of soft tissue defects after tumor resection in the oral cavity and oropharynx. Field report from 7 patient cases
Introduction To cover tumor resection defects in the oral cavity and oropharynx, flaps are available as a barrier against saliva, to protect against fistula formation and wound healing disorders. After resection of T1 to T2 findings, the defect can also heal secondarily, depending on the depth, which can lead to complications such as granulation, wound healing disorder, saliva fistulas and functional impairment. The decision must be weighed in terms of costs and risks. Case studies show that the use of a collagen matrix for mucosal overgrowth and as a barrier to enzymatic degradation is an alternative to secondary wound healing.
Method In 7 patients with T1 / T2 oropharyngeal malignancies mucograft were used after tumor resection instead of secondary wound healing. The depth of the defects must not exceed the underlying muscles. The healing was controlled and documented as part of the follow-up with regard to the complications mentioned. If one of the complications occurs, it would be covered with a flap graft at intervals.
Results There was no rejection reaction during the observation period. There was no wound healing disorder or inflammatory response. All patients experienced complete mucosal overgrowth.
Conclusion The coverage of superficial defects after tumor resection with mucograft leads to good wound healing without occurrence of complications. Prerequisite is the existence of soft tissue such as muscles. The application is limited as tissue replacement and barrier against enzymatic degradation of superficial defects.
10 June 2020 (online)
© Georg Thieme Verlag KG
Stuttgart · New York