Z Gastroenterol 2020; 58(05): e72
DOI: 10.1055/s-0040-1712239
VORTRÄGE

Alcohol consumption and the risk for colorectal adenoma

G Semmler
1   Department of Internal Medicine, General Hospital Oberndorf, Teaching Hospital of the Paracelsus Medical University Salzburg, Oberndorf, Austria
,
S Bachmayer
1   Department of Internal Medicine, General Hospital Oberndorf, Teaching Hospital of the Paracelsus Medical University Salzburg, Oberndorf, Austria
,
S Wernly
1   Department of Internal Medicine, General Hospital Oberndorf, Teaching Hospital of the Paracelsus Medical University Salzburg, Oberndorf, Austria
,
B Wernly
2   Department of Internal Medicine II, Paracelsus Medical University Salzburg, Salzburg, Austria
,
U Huber-Schönauer
1   Department of Internal Medicine, General Hospital Oberndorf, Teaching Hospital of the Paracelsus Medical University Salzburg, Oberndorf, Austria
,
E Aigner
3   Department of Internal Medicine I, Paracelsus Medical University Salzburg, Salzburg, Austria
,
C Datz
1   Department of Internal Medicine, General Hospital Oberndorf, Teaching Hospital of the Paracelsus Medical University Salzburg, Oberndorf, Austria
,
D Niederseer
4   Department of Cardiology, University Hospital Zurich, Zurich, Switzerland.
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Background and Aims Significant alcohol consumption (≥ 20g/day for female and ≥ 30g for male) has been proposed as a risk factor for colorectal cancer. However, results from meta-analyses are inconclusive. Thus, we aimed to clarify the role of alcohol consumption on the risk of colorectal adenoma.

Methods 4686 patients undergoing colonoscopy were included as part of a colorectal carcinoma colonoscopy screening program. Patients were characterized using biochemical and metabolic parameters. Data on alcohol consumption was extracted from detailed food frequency questionnaires and denoted as gramm (g)/week. For group comparison, patients were stratified according to their alcohol consumption into insignificant (none or  < 10g/week), moderate (10-130g/week) and significant (≥ 140g/week) alcohol consumption.

Results 52.0 % of patients were male with a mean age of 59.0 ± 10years and a mean BMI of 27.2 ± 4.7 kg/m2. Overall, any polyp was present in 1789 patients (38.2 %), any adenoma in 1480 patients (31.6 %) and any advanced adenoma in 343 patients (7.3 %). Among patients grouped according to their alcohol consumption, prevalence increased for any polyp (35.4 % vs. 42.1 % vs. 54.6 %), any adenoma (28.6 % vs. 35.9 % vs. 48.1 %) and any advanced adenoma (6.7 % vs. 8.7 % vs. 13.5 %, all p < 0.001). On multivariate linear regression analyses correcting for established risk factors such as age, gender, BMI, smoking status, physical activity, read meat intake, fruit and vegetable intake, alcohol consumption was associated with a significantly increased risk for any polyp (adjusted odds ratio [aOR] per 10g: 1.025, 95 % confidence interval [CI]: 1.004-1.046, p = 0.018), any adenoma (aOR: 1.028, 95 %CI: 1.007-1.050, p = 0.009), but not any advanced adenoma (aOR: 1.026, 95 %CI: 0.993-1.060, p = 0.123).

Conclusion We demonstrate an independent linear relationship between alcohol consumption and risk for colorectal adenoma. However, this was not confirmed for advanced adenoma. Thus, even low or moderate amounts of alcohol might contribute to the risk profile for colorectal adenoma.



Publication History

Article published online:
26 May 2020

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