Z Gastroenterol 2020; 58(05): e79
DOI: 10.1055/s-0040-1712255
POSTER
CED

ASSOCIATION BETWEEN HISTOLOGICAL INDICES AND ULCERATIVE COLITIS ACTIVITY MEASURES AMONG PATIENTS IN THE HICKORY (ETROLIZUMAB) OPEN-LABEL INDUCTION (OLI) COHORT

H Vogelsang
1   Medical University of Vienna, Vienna, Austria
,
L Peyrin-Biroulet
2   Université de Lorraine, Nancy, France
,
B Feagan
3   University of Western Ontario, London, Canada
,
RK Pai
4   Mayo Clinic, Phoenix, United States
,
A Boruvka
5   Roche Pharma Mississauga, Mississauga, Canada
,
YS Oh
6   Genentech, Inc., South San Francisco, United States
,
A Scherl
6   Genentech, Inc., South San Francisco, United States
,
A Scalori
7   Roche Products Limited, Welwyn Garden City, United Kingdom
,
P Arrisi
7   Roche Products Limited, Welwyn Garden City, United Kingdom
,
S Tole
6   Genentech, Inc., South San Francisco, United States
,
DT Rubin
8   University of Chicago Medicine, Chicago, United States
› Author Affiliations
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BACKGROUND Cross-sectional studies in UC have shown an association between histological and clinical measures of disease activity, but few longitudinal studies have evaluated this relationship. Using open-label induction data from the HICKORY study (NCT02100696), we analyzed this correlation at end of induction.

METHODS Baseline and Week 14 biopsies were scored using the Robarts histopathology index (RHI) and the Nancy histological index (NHI) in patients who had active baseline histology (NHI  >  1 and RHI  >  3) (n = 97). Histological outcomes were characterized by presence or absence of neutrophils. Pairwise associations were quantified by Spearman correlation and Cohen’s kappa coefficients. ΔRHI and ΔNHI comparison determined the presence of a minimal clinically important difference (MCID) in Mayo Clinic score (MCS; ΔMCS ≥  3).

RESULTS At Week 14 22 %, 23 % and 8 % of patients achieved resolution of neutrophilic inflammation, endoscopic improvement (ES ≤ 1) and endoscopic remission (ES = 0), respectively; NHI ≤ 1 was achieved in 55 % (12/22) of patients with ES ≤ 1 and 75 % (6/8) of patients with ES = 0. ΔNHI and ΔRHI were highly correlated (ρ = 0.91). There was little to no association between laboratory results and ΔNHI/ΔRHI/ΔES. A weak correlation was seen between ΔNHI/ΔRHI and ΔES (ρ = 0.26-0.27) and between ΔNHI/ΔRHI and change in rectal bleeding and stool frequency. NHI, RHI and ES agreement with symptomatic outcomes were weak to moderate (κ = 0.28-0.45). Difference in the mean grouped by achievement of ΔMCS ≥ 3 suggests MCIDs in ΔNHI and ΔRHI of 1 and 9, respectively.

CONCLUSIONS The analysis showed no associations between changes in histological scores and in laboratory results. The correlation was weak between histologic and endoscopic score change, and weak to modest between histologic scores and symptoms at the end of induction. Previously presented: Peyrin-Biroulet L et al. ECCO 2019.



Publication History

Article published online:
26 May 2020

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