Tierarztl Prax Ausg K Kleintiere Heimtiere 2020; 48(03): 218-219
DOI: 10.1055/s-0040-1712580
Experimentell e Pathologie

Experimentell e Pathologie

Spontaneous Zymbal’s gland carcinoma with splenic and lymph node metastasis in Wistar rat
O. B. Akanbi
1   Department of Veterinary Pathology, University of Ilorin, Nigeria
› Author Affiliations
 

Introduction Zymbal’s gland in the external ear canal in the rat is a specialized sebaceous gland. Neoplastic changes of it can be benign or malignant. An adult Wistar rat from a colony of 400 developed a large sub-auricular facial exophytic pedunculated 2 × 2.5 cm hemorrhagic and ulcerating mass.

Material and methods Tumor, spleen and lymph node cuts of 0.5 × 0.5 cm in diameter were formalinized and processed for histological examination using hematoxylin and eosin stain.

Findings Facial nerve paralysis, head tilt, circling and lethargy were signs before euthanized. Mass revealed numerous lobulated structures expanding the dermis and compressing the epidermis. Neoplastic lobules were unencapsulated and invasive and showed variable degree of sebaceous differentiation and a predominantly glandular pattern with tumour cells exhibiting nuclear atypia. Malignancy was characterized by pleomorphism and metastasis. Infiltrating cells admixed with Langhans-type multinucleate giant cell and syncytial tumour foreign body-type multinucleate giant cells with bizarre shaped, multilobed, densely basophilic nuclei and karyomegaly were present within the spleen and lymph node respectively.

Conclusion This microscopic features of this tumour are consistent with a Zymbal’s gland carcinoma. Although a rare type of spontaneous tumor, the involvement of a chemical carcinogen was ruled out.



Publication History

Article published online:
08 July 2020

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