CC BY 4.0 · Eur J Dent 2020; 14(03): 462-466
DOI: 10.1055/s-0040-1714037
Review Article

Periostin: Immunomodulatory Effects on Oral Diseases

1  Department of Prosthodontics and Dental Implantology, College of Dentistry, King Faisal University, Al Ahsa, Saudi Arabia
,
Maria Mali
2  Department of Orthodontics, Islamic International Dental College, Riphah International University, Islamabad, Pakistan
,
3  Department of Restorative Dentistry, College of Dentistry, King Faisal University, Al Ahsa, Saudi Arabia
,
4  Department of Restorative Dentistry, College of Dentistry, Taibah University, Madinah Al-Munawarah, Madinah, Saudi Arabia
5  Department of Dental Materials, Islamic International Dental College, Riphah International University, Islamabad, Pakistan
,
Rabia Sannam Khan
6  Department of Bioengineering, Lancaster University, Lancaster, United Kingdom
,
Muhammad Latif
7  Centre for Genetics and Inherited Diseases, College of Medicine, Taibah University, Madinah Al-Munawarah, Madinah, Saudi Arabia
› Author Affiliations
Funding None.

Abstract

Periostin is a microcellular adapter protein. It plays a wide range of essential roles during the development and in immunomodulation. Periostin is a prominent contributor during the process of angiogenesis, tumorigenesis, and cardiac repair. It is expressed in periodontal ligaments, tendons, skin, adipose tissues, muscle, and bone. This is a protein-based biomolecule that has the diagnostic and monitoring capability and can potentially be used as a biomarker to detect physiological and pathological conditions. The aim of the present review was to explore the periostin morphology and associated structural features. Additionally, periostin’s immunomodulatory effects and associated biomarkers in context of oral diseases have been discussed.



Publication History

Publication Date:
20 July 2020 (online)

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