Pediatric Neuromuscular Disorders in Ile-Ife, Nigeria: Pattern and the Challenges with Management

Abstract

The aim of this study was to describe the presentation pattern and challenges with the management of pediatric neuromuscular disorders (NMDs) in Ile-Ife, Nigeria through retrospective review of their clinical records. We recruited 24 children aged 14 days to 15 years with a male preponderance (male-to-female ratio = 2.4:1). Late presentation was a prominent feature which was highest among children with myopathies with a mean duration of symptoms of 46.5 ± 33.4 months before presentation. Peripheral neuropathy was the most common type of NMDs (63.0%). Among these, injection nerve palsy from the use of wrong site for intramuscular injections was the most common (60.0%). Nonavailability of electrophysiologic and genetic testing as well as appropriate medications was the major challenges. Acquired NMDs are common in our setting. There is a need to improve preventive measures of acquired NMDs and early diagnosis of the inherited types.

Keywords

neuromuscular disease - peripheral neuropathy - muscular dystrophy - childhood

Publikationsverlauf

Eingereicht: 07. Februar 2020

Angenommen: 29. Mai 2020

Artikel online veröffentlicht:
05. August 2020

• References

• 1 Dowling JJ, D Gonorazky H, Cohn RD, Campbell C. Treating pediatric neuromuscular disorders: the future is now. Am J Med Genet A 2018; 176 (04) 804-841
• 2 Chung B, Wong V, Ip P. Prevalence of neuromuscular diseases in Chinese children: a study in southern China. J Child Neurol 2003; 18 (03) 217-219
• 3 Darin N, Tulinius M. Neuromuscular disorders in childhood: a descriptive epidemiological study from western Sweden. Neuromuscul Disord 2000; 10 (01) 1-9
• 4 Emery AEH. Population frequencies of inherited neuromuscular diseases--a world survey. Neuromuscul Disord 1991; 1 (01) 19-29
• 5 Rose L, McKim D, Leasa D. et al. Trends in incidence, prevalence, and mortality of neuromuscular disease in Ontario, Canada: a population-based retrospective cohort study (2003-2014). PLoS One 2019; 14 (03) e0210574
• 6 Hughes MI, Hicks EM, Nevin NC, Patterson VH. The prevalence of inherited neuromuscular disease in Northern Ireland. Neuromuscul Disord 1996; 6 (01) 69-73
• 7 Deenen JC, Horlings CG, Verschuuren JJ, Verbeek AvanEB, van Engelen BG. The epidemiology of neuromuscular disorders: a comprehensive overview of the literature. J Neuromuscul Dis 2015; 2 (01) 73-85
• 8 Bhatt JM. The epidemiology of neuromuscular diseases. Neurol Clin 2016; 34 (04) 999-1021
• 9 Merlini L, Stagni SB, Marri E, Granata C. Epidemiology of neuromuscular disorders in the under-20 population in Bologna Province, Italy. Neuromuscul Disord 1992; 2 (03) 197-200
• 10 Mohamed IN, Elseed MA, Hamed AA. Clinical profile of pediatric neurological disorders. Child Neurol Open 2016; 3: 2329048X1562354
• 11 Osuntokun BO, Adeuja AO, Schoenberg BS. et al. Neurological disorders in Nigerian Africans: a community-based study. Acta Neurol Scand 1987; 75 (01) 13-21
• 12 Oyinlade OA, Lagunju IA, Adebayo BE. Neuromuscular disease mimicking myasthenia gravis in a Nigerian female adolescent: could this be nemaline rod disease?. Ann Ib Postgrad Med 2016; 14 (02) 110-113
• 13 Odinaka KK, Nwolisa EC. Challenges in the management of the child with Duchenne muscular dystrophy in a resource poor setting: a case report. Pan Afr Med J 2014; 19: 227
• 14 Ajala OA, Olayiwola W. An assessment of the growth of Ile-Ife, Osun State Nigeria, using multitemporal imageries. J Geography Geology 2013; 5 (02) 43
• 15 Oyedeji GA. Socio economic and cultural background of hospitalized children in Ilesha. Niger J Paediatr 1985; 12: 111-117
• 16 Kakati A, Bhat D, Devi BI, Shukla D. Injection nerve palsy. J Neurosci Rural Pract 2013; 4 (01) 13-18
• 17 Theadom A, Rodrigues M, Roxburgh R. et al. Prevalence of muscular dystrophies: a systematic literature review. Neuroepidemiology 2014; 43 (3-4): 259-268