CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol 2021; 25(03): e379-e382
DOI: 10.1055/s-0040-1715148
Original Research

The Role of FNAC in the Diagnosis and Management of Warthin Tumour: Analysis of 74 Cases

1   Alexandria Medical School, Alexandria, Egypt
,
Sundus Alsedra
1   Alexandria Medical School, Alexandria, Egypt
,
Daron Cope
2   Department of Otolaryngology-Head and Neck Surgery, NSW Health, North Sydney, New South Wales, Australia
,
Ahmed Youssef
1   Alexandria Medical School, Alexandria, Egypt
› Author Affiliations

Abstract

Introduction After pleomorphic adenoma, Warthin tumor gets its popularity as the second most common benign neoplasm of the parotid gland. Fine-needle aspiration cytology (FNAC) is the most cost-effective and minimally-invasive way to determine the histological character of a parotid gland tumor.

Objective To determine the accuracy of FNAC in the diagnosis of Warthin Tumour.

Methods A retrospective study conducted between 2014 and 2018. Out of 243 FNACs performed for parotid lesions, a histopathological correlation was established in 74 cases to reveal the accuracy of FNAC in the diagnosis of Warthin tumor.

Results A total of 243 FNACs of parotid lesions were performed, and a histopathological correlation was established in 74 (30.4%) cases. Later on, we confirmed that 16 (21.6%) out of these 74 patients had cases of Warthin tumor. In total, 15 (20.3%) out of those 74 cases were confirmed as Warthin tumors on the initial cytology, which revealed a true positive concordance between the cytology and the final histological diagnosis; 55/74 (74%) were true negative results; on the other hand, 1/74 (1.4%) was a false negative, and 3/74 (4.1%) were false positive results. The sensitivity of the FNAC in the diagnosis of Warthin tumor was of 93%, while the specificity was of 94.8%, and the accuracy, of 94.6%.

Conclusion In the present study, FNAC had a high diagnostic accuracy, reaching 94%.



Publication History

Received: 11 May 2020

Accepted: 21 June 2020

Article published online:
24 September 2020

© 2020. Fundação Otorrinolaringologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Guntinas-Lichius O, Klussmann JP, Wittekindt C, Stennert E. Parotidectomy for benign parotid disease at a university teaching hospital: outcome of 963 operations. Laryngoscope 2006; 116 (04) 534-540
  • 2 Renehan A, Gleave EN, Hancock BD, Smith P, McGurk M. Long-term follow-up of over 1000 patients with salivary gland tumours treated in a single centre. Br J Surg 1996; 83 (12) 1750-1754
  • 3 Maiorano E, Lo Muzio L, Favia G, Piattelli A. Warthin's tumour: a study of 78 cases with emphasis on bilaterality, multifocality and association with other malignancies. Oral Oncol 2002; 38 (01) 35-40
  • 4 Teymoortash A, Krasnewicz Y, Werner JA. Clinical features of cystadenolymphoma (Warthin's tumor) of the parotid gland: a retrospective comparative study of 96 cases. Oral Oncol 2006; 42 (06) 569-573
  • 5 Teymoortash A, Werner JA. Tissue that has lost its track: Warthin's tumour. Virchows Arch 2005; 446 (06) 585-588
  • 6 Teymoortash A, Schrader C, Shimoda H, Kato S, Werner JA. Evidence of lymphangiogenesis in Warthin's tumor of the parotid gland. Oral Oncol 2007; 43 (06) 614-618
  • 7 Espinoza S, Felter A, Malinvaud D. et al. Warthin's tumor of parotid gland: Surgery or follow-up? Diagnostic value of a decisional algorithm with functional MRI. Diagn Interv Imaging 2016; 97 (01) 37-43
  • 8 Schwalje AT, Uzelac A, Ryan WR. Growth rate characteristics of Warthin's tumours of the parotid gland. Int J Oral Maxillofac Surg 2015; 44 (12) 1474-1479
  • 9 Patel DK, Morton RP. Demographics of benign parotid tumours: Warthin's tumour versus other benign salivary tumours. Acta Otolaryngol 2016; 136 (01) 83-86
  • 10 Lee DH, Yoon TM, Lee JK, Lim SC. Surgical treatment outcomes of patients with bilateral warthin tumors in the parotid gland. Indian J Otolaryngol Head Neck Surg 2014; 66 (Suppl. 01) 303-306
  • 11 Peter Klussmann J, Wittekindt C, Florian Preuss S, Al Attab A, Schroeder U, Guntinas-Lichius O. High risk for bilateral Warthin tumor in heavy smokers--review of 185 cases. Acta Otolaryngol 2006; 126 (11) 1213-1217
  • 12 Som PM, Brandwein MS. Salivary glands: anatomy and pathology. In: Som PM, Curtin HD. , editors. Head and neck imaging. 4th ed. St. Louis, Mo: Mosby; 2005: 2003-133
  • 13 Bradley PT, Paleri V, Homer JJ. Consensus statement by otolaryngologists on the diagnosis and management of benign parotid gland disease. Clin Otolaryngol 2012; 37 (04) 300-304
  • 14 Yu GY, Ma DQ, Liu XB, Zhang MY, Zhang Q. Local excision of the parotid gland in the treatment of Warthin's tumour. Br J Oral Maxillofac Surg 1998; 36 (03) 186-189
  • 15 Faur A, Lazăr E, Cornianu M, Dema A, Vidita CG, Găluşcan A. Warthin tumor: a curious entity--case reports and review of literature. Rom J Morphol Embryol 2009; 50 (02) 269-273
  • 16 Jayaram G, Verma AK, Sood N, Khurana N. Fine needle aspiration cytology of salivary gland lesions. J Oral Pathol Med 1994; 23 (06) 256-261
  • 17 Naz S, Hashmi AA, Khurshid A. et al. Diagnostic role of fine needle aspiration cytology (FNAC) in the evaluation of salivary gland swelling: an institutional experience. BMC Res Notes 2015; 8: 101
  • 18 Klijanienko J, Vielh P. Fine-needle sampling of salivary gland lesions. II. Cytology and histology correlation of 71 cases of Warthin's tumor (adenolymphoma). Diagn Cytopathol 1997; 16 (03) 221-225
  • 19 Ballo MS, Shin HJ, Sneige N. Sources of diagnostic error in the fine-needle aspiration diagnosis of Warthin's tumor and clues to a correct diagnosis. Diagn Cytopathol 1997; 17 (03) 230-234
  • 20 Verma K, Kapila K. Salivary gland tumors with a prominent oncocytic component. Cytologic findings and differential diagnosis of oncocytomas and Warthin's tumor on fine needle aspirates. Acta Cytol 2003; 47 (02) 221-226
  • 21 Parwani AV, Ali SZ. Diagnostic accuracy and pitfalls in fine-needle aspiration interpretation of Warthin tumor. Cancer 2003; 99 (03) 166-171
  • 22 Chakrabarti I, Basu A, Ghosh N. Oncocytic lesion of parotid gland: A dilemma for cytopathologists. J Cytol 2012; 29 (01) 80-82
  • 23 Suzuki K, Iwai H, Kaneko T, Sakaguchi M, Hoshino S, Inaba M. Induction of parotitis by fine-needle aspiration in parotid Warthin's tumor. Otolaryngol Head Neck Surg 2009; 141 (02) 282-284
  • 24 So T, Sahovaler A, Nichols A. et al. Utility of clinical features with fine needle aspiration biopsy for diagnosis of Warthin tumor. J Otolaryngol Head Neck Surg 2019; 48 (01) 41
  • 25 Yariv O, Popovtzer A, Wasserzug O. et al. Usefulness of ultrasound and fine needle aspiration cytology of major salivary gland lesions. Am J Otolaryngol 2020; 41 (01) 102293
  • 26 Suzuki M, Kawata R, Higashino M. et al. Values of fine-needle aspiration cytology of parotid gland tumors: A review of 996 cases at a single institution. Head Neck 2019; 41 (02) 358-365
  • 27 Cohen MB, Reznicek MJ, Miller TR. Fine-needle aspiration biopsy of the salivary glands. Pathol Annu 1992; 27 (Pt 2): 213-245
  • 28 Qizilbash AH, Sianos J, Young JEM, Archibald SD. Fine needle aspiration biopsy cytology of major salivary glands. Acta Cytol 1985; 29 (04) 503-512
  • 29 Layfield LJ, Glasgow BJ. Diagnosis of salivary gland tumors by fine-needle aspiration cytology: a review of clinical utility and pitfalls. Diagn Cytopathol 1991; 7 (03) 267-272
  • 30 Neelam S, Borah P. Warthin tumor: Cytohistological spectrum with emphasis on diagnostic difficulties. Diagn Cytopathol 2018; 46 (07) 613-619
  • 31 Seifert G, Bull HG, Donath K. Histologic subclassification of the cystadenolymphoma of the parotid gland. Analysis of 275 cases. Virchows Arch A Pathol Anat Histol 1980; 388 (01) 13-38
  • 32 Nir H, Cohen J, Neuman T, Weinberger JM, Eliashar R. Is surgery for an FNA proven Warthins Tumor Passé?. J Cancer Ther Res 2012; •••: 1-4
  • 33 Flezar M, Pogacnik A. Warthin's tumour: unusual vs. common morphological findings in fine needle aspiration biopsies. Cytopathology 2002; 13 (04) 232-241
  • 34 Lewis DR, Webb AJ, Lott MF, Brookes ST, Farndon JR. Improving cytological diagnosis and surgical management of parotid adenolymphoma. Br J Surg 1999; 86 (10) 1275-1279
  • 35 Dong HL, Yoon TM, Lee JK, Lim SC. Surgical treatment strategy in Warthin Tumor of the parotid gland. BJORL 2019; 85 (05) 546-550
  • 36 Fulciniti F, Califano L, Zupi A, Vetrani A. Accuracy of fine needle aspiration biopsy in head and neck tumors. J Oral Maxillofac Surg 1997; 55 (10) 1094-1097
  • 37 Filopoulos E, Angeli S, Daskalopoulou D, Kelessis N, Vassilopoulos P. Pre-operative evaluation of parotid tumours by fine needle biopsy. Eur J Surg Oncol 1998; 24 (03) 180-183