CC BY-NC-ND 4.0 · Journal of Neuroanaesthesiology and Critical Care
DOI: 10.1055/s-0040-1715555
Case Report

Use of Dexmedetomidine for Magnetic Resonance Imaging under Sedation in a Pediatric Patient with Phenylketonuria

1  Department of Neuroanesthesia and Neurocritical Care, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
2  Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
,
Rajeeb K. Mishra
1  Department of Neuroanesthesia and Neurocritical Care, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
2  Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
,
Amit Goyal
1  Department of Neuroanesthesia and Neurocritical Care, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
2  Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
,
Venkatapura J. Ramesh
1  Department of Neuroanesthesia and Neurocritical Care, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
2  Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
,
Prathamesh M. Patwardhan
1  Department of Neuroanesthesia and Neurocritical Care, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
2  Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
› Author Affiliations

Abstract

Phenylketonuria (PKU) is an inborn error of metabolism caused by a deficiency of the enzyme phenylalanine hydroxylase which results in accumulation of phenylalanine. Patients of PKU presents with seizures, mental retardation, and organ damage and possess a unique challenge to the anesthesiologists when they need anesthetics for diagnostic or surgical procedures. There is limited literature regarding the safety of various anesthetic drugs in PKU patients. None of them reported the use of dexmedetomidine as safer sedative option for such patients. Therefore, we describe the management of such a case posted for magnetic resonance imaging under dexmedetomidine sedation.



Publication History

Publication Date:
19 November 2020 (online)

© 2020. Indian Society of Neuroanaesthesiology and Critical Care. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India