PDF herunterladen
Am J Perinatol 2020; 37(12): 1280-1282
DOI: 10.1055/s-0040-1715643
Short Communication

A Case Report to Assess Passive Immunity in a COVID Positive Pregnant Patient

Lorraine E. Toner
1   Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York
2   Division of Maternal Fetal Medicine, Icahn School of Medicine at Mount Sinai, New York, New York
,
Shari E. Gelber
1   Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York
3   Maternal Fetal Medicine Associates, PLLC, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York
,
Juan A. Pena
1   Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York
2   Division of Maternal Fetal Medicine, Icahn School of Medicine at Mount Sinai, New York, New York
,
Nathan S. Fox
1   Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York
3   Maternal Fetal Medicine Associates, PLLC, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York
,
Andrei Rebarber
1   Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York
3   Maternal Fetal Medicine Associates, PLLC, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York
› Institutsangaben
› Weitere Informationen
   Lizenzen und Reprints

Abstract

Introduction Data regarding transplacental passage of maternal coronavirus disease 2019 (COVID-19) antibodies and potential immunity in the newborn is limited.

Case Report We present a 25-year-old multigravida with known red blood cell isoimmunization, who was found to be COVID-19 positive at 27 weeks of gestation while undergoing serial periumbilical blood sampling and intrauterine transfusions. Maternal COVID-19 antibody was detected 2 weeks after positive molecular testing. Antibodies were never detected on cord blood samples from two intrauterine fetal cord blood samples as well as neonatal cord blood at the time of delivery.

Conclusion This case demonstrates a lack of passive immunity of COVID-19 antibodies from a positive pregnant woman to her fetus, neither in utero nor at the time of birth. Further studies are needed to understand if passage of antibodies can occur and if that can confer passive immunity in the newborn.

Key Points

  • Passive immunity should not be assumed in COVID-19 infection in pregnancy.

  • Isoimmunization may impair passive immunity of certain antibodies.

  • Vaccination to or maternal infection of COVID-19 may not be protective for the fetus.

Keywords

SARS-CoV-2 - pregnancy - COVID-19 - passive immunity


Publikationsverlauf

Eingereicht: 01. Juli 2020

Angenommen: 21. Juli 2020

Artikel online veröffentlicht:
13. August 2020

© 2020. Thieme. All rights reserved.

Thieme Medical Publishers
333 Seventh Avenue, New York, NY 10001, USA.

 

  • References

  • 1 Fox NS, Melka S. COVID-19 in pregnant women: case series from one large new york city obstetrical practice. Am J Perinatol 2020; 37 (10) 1002-1004
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 2 Lu X, Zhang L, Du H. , et al; Chinese Pediatric Novel Coronavirus Study Team. SARS-CoV-2 infection in children. N Engl J Med 2020; 382 (17) 1663-1665
    CrossrefPubMedGoogle Scholar
  • 3 Chen H, Guo J, Wang C. , et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet 2020; 395 (10226): 809-815
    CrossrefPubMedGoogle Scholar
  • 4 Baud D, Greub G, Favre G. , et al. Second-trimester miscarriage in a pregnant woman with SARS-CoV-2 infection. JAMA 2020; DOI: 10.1001/jama.2020.7233.
    CrossrefPubMedGoogle Scholar
  • 5 Zeng H, Xu C, Fan J. , et al. Antibodies in infants born to mothers with COVID-19 pneumonia. JAMA 2020; DOI: 10.1001/jama.2020.4861.
    CrossrefPubMedGoogle Scholar
  • 6 Wilcox CR, Holder B, Jones CE. Factors affecting the FcRn-mediated transplacental transfer of antibodies and implications for vaccination in pregnancy. Front Immunol 2017; 8: 1294
    CrossrefPubMedGoogle Scholar
  • 7 Martinez DR, Fong Y, Li SH. , et al. Fc IgG in HIV-infected women. Cell 2019; 178 (01) 190-201.e11
    CrossrefPubMedGoogle Scholar