Semin Reprod Med 2020; 38(01): 061-073
DOI: 10.1055/s-0040-1716409
Review Article

Impairment of Uterine Contractility Is Associated with Unexplained Infertility

Sarah Hunt
1  Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia
2  Monash Health, Clayton, Australia
3  Monash IVF, Richmond, Australia
,
Karim S. Abdallah
1  Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia
4  Department of Obstetrics and Gynaecology, Assiut University, Women's Health Hospital, Assiut, Egypt
,
Ernest Ng
5  Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong, Hong Kong
,
Luk Rombauts
1  Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia
2  Monash Health, Clayton, Australia
3  Monash IVF, Richmond, Australia
,
Beverley Vollenhoven
1  Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia
2  Monash Health, Clayton, Australia
3  Monash IVF, Richmond, Australia
,
Ben W. Mol
1  Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia
2  Monash Health, Clayton, Australia
6  Aberdeen Centre for Women's Health Research, University of Aberdeen, Aberdeen, United Kingdom
› Author Affiliations

Abstract

The uterine junctional zone represents the juncture between endometrium and myometrium. The junctional zone is hormonally dependent and displays continuous peristaltic activity throughout the menstrual cycle in the nonpregnant state which is concerned with sperm transport and embryo implantation. Peristalsis may be observed using various invasive and noninvasive modalities, of which ultrasound is the most readily applied in the clinical setting. Women with pelvic pathology display alterations in uterine peristalsis which may contribute to infertility. Characterization of peristalsis in infertility subgroups, the development of a subjective peristalsis tool, and the application of potential therapeutics to an assisted reproductive treatment setting are the subject of ongoing investigation. Meta-analysis indicates a potential role for oxytocin antagonist in the improvement of fertility treatments.



Publication History

Publication Date:
14 October 2020 (online)

© 2020. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA