CC BY-NC-ND 4.0 · Indian Journal of Neurotrauma 2021; 18(01): 26-31
DOI: 10.1055/s-0040-1717216
Original Article

A Randomised Interventional Study to Compare Autologous and Nonautologous Dural Substitutes Among Traumatic Brain Injury Patients

Vir Abhimanyu Pandit
1  Department of Neurosurgery, Narayan Medical College and Hospital, Jamuhar, Rohtas, Bihar, India
,
Rajesh Kumar Sharma
2  Department of Neurosurgery, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS), Dr Ram Manohar Lohia Hospital, New Delhi, India
,
Suryanarayanan Bhaskar
3  Department of Neurosurgery, All Indian Institute of Medical Science, Jodhpur, India
,
Amanjeet Singh Kindra
4  Shah Neuro and Trauma Centre Kaithal, Haryana, India
,
Ajay Choudhary
2  Department of Neurosurgery, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS), Dr Ram Manohar Lohia Hospital, New Delhi, India
,
LN Gupta
2  Department of Neurosurgery, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS), Dr Ram Manohar Lohia Hospital, New Delhi, India
› Author Affiliations
Funding None.

Abstract

Objectives To determine and compare the effectiveness and safety of galea-pericranium autologous dural graft with nonautologous polypropylene (G-patch) dural substitute among traumatic brain injury (TBI) patients.

Methods A prospective interventional randomized comparative study was conducted at the Department of Neurosurgery from November 2013 to March 2015 after obtaining approval from the institutional ethicas committee. The study population included 50 cases of TBI which were divided into two groups of 25 each by the randomization technique and were treated either with autologous duraplasty (galea-pericranium) or nonautologous polypropylene (G-patch) dural substitute. The outcomes measured were time to duraplasty, blood loss, hospital stay, and the incidence of complications with the two techniques. The data were entered in a MS Excel spreadsheet and analysis was done using Statistical Package for Social Sciences (SPSS) version 21.0. A p value of < 0.05 was considered statistically significant.

Results The average time to harvest galea-pericranium was 5 minutes. Compared with the patients undergoing G-patch, the patients in group pericranium had comparable duraplasty time (minutes) (34.32 vs. 27.80, p = 0.44), significantly lower drain output (54.8 vs. 74.5, p = 0.017), comparable blood loss (322 vs. 308, p = 0.545), comparable blood transfusion (24% vs. 16%, p = 0.48), significantly lesser duration of hospital stay (8.6 vs. 10.44, p = 0.028), comparable wound infection (8% vs. 16%, p = 0.384), and comparable cerebrospinal fluid (CSF) leak (0% vs. 8%, p = 0.149).

Conclusion The study showed that galea-pericranium and polypropylene dural patch are equally effective and safe dural substitutes in providing a dural seal to minimize the CSF leaks and infections among posttraumatic brain injury patients.



Publication History

Publication Date:
29 September 2020 (online)

© 2020. Neurotrauma Society of India. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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