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Synlett 2022; 33(05): 429-439
DOI: 10.1055/s-0040-1719840
DOI: 10.1055/s-0040-1719840
account
Group-Selective Approaches to Complex Natural Product Synthesis: Three Examples of Diastereotopos-Selective Reactions
This work was supported by Japan Society for the Promotion of Science (JSPS KAKENHI Grant Numbers JP23000006, JP16H06351, JP16H01137, and JP16H04107).
![](https://www.thieme-connect.de/media/synlett/202205/lookinside/thumbnails/st-2021-a0308-a_10-1055_s-0040-1719840-1.jpg)
Dedicated to Profs. Masaji Ohno, Susumu Kobayashi and Reinhard W. Hoffmann
Abstract
This Account showcases three diastereotopos-selective reactions exploited in our complex natural syntheses.
1 Introduction
2 Malyngolide: Hydroalumination of Bisalkynyl tert-Alcohols
3 Cavicularin: Acetal Cleavage
4 Carthamin: Bromoacetoxylation
5 Conclusions
Key words
asymmetrization - differentiation - group selectivity - natural product synthesis - topos selectivityPublication History
Received: 30 August 2021
Accepted after revision: 08 September 2021
Article published online:
13 October 2021
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