CC BY-NC-ND 4.0 · Journal of Clinical Interventional Radiology ISVIR 2020; 4(03): 159-166
DOI: 10.1055/s-0040-1721532
Original Article

Computed Tomography-Guided Vertebral Biopsy in Suspected Tuberculous Spondylodiscitis: Comparing a New Navigational Tram-Track Technique versus Conventional Method

1   Department of Radiodiagnosis, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
,
1   Department of Radiodiagnosis, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
,
2   Central Institute of Orthopedics, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
,
1   Department of Radiodiagnosis, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
,
1   Department of Radiodiagnosis, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
,
3   Department of Anesthesia, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
› Author Affiliations

Abstract

Introduction Computed tomography (CT)-guided vertebral biopsy is always recommended for histopathological and microbiological confirmation in cases of tuberculous spondylodiscitis and for antimycobacterial drug sensitivity testing.

Aim To compare the conventional technique and a novel axis-defined tram-track technique of CT-guided vertebral biopsy in suspected tuberculous spondylodiscitis.

Materials and Methods Sixty-seven patients of clinico-radiologically suspected tuberculous spondylodiscitis referred for CT-guided vertebral biopsy were categorized into two groups: “Group A” patients (n = 32) underwent biopsy by conventional technique, and “Group B” patients (n = 35) by axis-defined tram-track technique. The time taken for procedure, radiation exposure, and any procedural complications were recorded for both the groups.

Results A statistically significant difference in procedure time and mean radiation dose was observed between the two groups: a longer procedural time was required in “Group A” (52.5 ± 3.5 minutes) as compared to “Group B” (37.3 ± 3.6 minutes) (p < 0.0001); and mean radiation dose (CTDIvol) in “Group A” and “Group B” was 8.64 ± 1.06 mGy and 5.73 ± 0.71 mGy, respectively (p < 0.0001). However, the difference in complication rate and tissue yield for successful diagnosis of the biopsies in the two groups was found to be statistically insignificant.

Conclusion Axis-defined tram-track technique was found to have a significantly shorter procedural time as well as lower radiation exposure compared to the conventional technique of vertebral biopsy in our study.



Publication History

Article published online:
24 December 2020

© 2020. Indian Society of Vascular and Interventional Radiology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 
  • References

  • 1 Trecarichi EM, Di Meco E, Mazzotta V, Fantoni M. Tuberculous spondylodiscitis: epidemiology, clinical features, treatment, and outcome. Eur Rev Med Pharmacol Sci 2012; 16 (Suppl. 02) 58-72
  • 2 Jain AK, Jaggi KR, Bhayana H, Saha R. Drug-resistant spinal tuberculosis. Indian J Orthop 2018; 52 (02) 100-107
  • 3 Chew FS, Kline MJ. Diagnostic yield of CT-guided percutaneous aspiration procedures in suspected spontaneous infectious diskitis. Radiology 2001; 218 (01) 211-214
  • 4 Peh W. CT-guided percutaneous biopsy of spinal lesions. Biomed Imaging Interv J 2006; 2 (03) e25
  • 5 Rimondi E, Staals EL, Errani C. et al. Percutaneous CT-guided biopsy of the spine: results of 430 biopsies. Eur Spine J 2008; 17 (07) 975-981
  • 6 Lien SB, Liou NH, Wu SS. Analysis of anatomic morphometry of the pedicles and the safe zone for through-pedicle procedures in the thoracic and lumbar spine. Eur Spine J 2007; 16 (08) 1215-1222
  • 7 Robertson RC, Ball RP. Destructive spine lesions: diagnosis by needle biopsy. J Bone Joint Surg. 1935; 57: 749-758
  • 8 Stahl DC, Jacobs B. Diagnosis of obscure lesions of the skeleton. Evaluation of biopsy methods. JAMA 1967; 201 (04) 229-231
  • 9 Bender CE, Berquist TH, Wold LE. Imaging-assisted percutaneous biopsy of the thoracic spine. Mayo Clin Proc 1986; 61 (12) 942-950
  • 10 Pierot L, Boulin A. Percutaneous biopsy of the thoracic and lumbar spine: transpedicular approach under fluoroscopic guidance. AJNR Am J Neuroradiol 1999; 20 (01) 23-25
  • 11 Adapon BD, Legada Jr BD, Lim EV, Silao Jr JV, Dalmacio-Cruz A. CT-guided closed biopsy of the spine. J Comput Assist Tomogr 1981; 5 (01) 73-78
  • 12 Puri A, Shingade VU, Agarwal MG. et al. CT-guided percutaneous core needle biopsy in deep seated musculoskeletal lesions: a prospective study of 128 cases. Skeletal Radiol 2006; 35 (03) 138-143
  • 13 Shpilberg KA, Delman BN, Tanenbaum LN, Esses SJ, Subramaniam R, Doshi AH. Radiation dose reduction in CT-guided spine biopsies does not reduce diagnostic yield. AJNR Am J Neuroradiol 2014; 35 (12) 2243-2247
  • 14 Ortiz A. Image-Guided Percutaneous Spine Biopsy. Switzerland: Springer International Publishing; 2017: 75-106
  • 15 Singh DK, Kumar N, Nayak BK. et al. Approach-based techniques of CT-guided percutaneous vertebral biopsy. Diagn Interv Radiol 2020; 26 (02) 143-146
  • 16 Guberina N, Forsting M, Ringelstein A. et al. Radiation exposure during CT-guided biopsies: recent CT machines provide markedly lower doses. Eur Radiol 2018; 28 (09) 3929-3935
  • 17 Bress A, Metzler S, Plastaras C, Nguyen C, Schuster JM, Pukenas B. “Scout No Scan” technique reduces patient radiation exposure during CT-guided spine biopsy. AJR Am J Roentgenol 2017; 209 (05) 1158-1161
  • 18 Li X, Yang K, Liu B. Exam-level dose monitoring in CT: quality metric consideration for multiple series acquisitions. Med Phys 2019; 46 (04) 1575-1580
  • 19 Heyer CM, Brus LJ, Peters SA, Lemburg SP. Efficacy of CT-guided biopsies of the spine in patients with spondylitis–an analysis of 164 procedures. Eur J Radiol 2012; 81 (03) e244-e249
  • 20 Hua WB, Wu Q, Zhang B. et al. Initial CT-guided percutaneous biopsy of vertebral lesions: Evaluation of its diagnostic accuracy and clinical value. J Huazhong Univ Sci Technolog Med Sci 2015; 35 (04) 569-573
  • 21 Lee SA, Chiu CK, Chan CYW. et al. The clinical utility of fluoroscopic versus CT guided percutaneous transpedicular core needle biopsy for spinal infections and tumours: a randomized trial. Spine J 2020; 20 (07) 1114-1124
  • 22 Yaffe D, Greenberg G, Leitner J, Gipstein R, Shapiro M, Bachar GN. CT-guided percutaneous biopsy of thoracic and lumbar spine: a new coaxial technique. AJNR Am J Neuroradiol 2003; 24 (10) 2111-2113
  • 23 Yang SY, Oh E, Kwon JW, Kim HS. Percutaneous image-guided spinal lesion biopsies: factors affecting higher diagnostic yield. AJR Am J Roentgenol 2018; 211 (05) 1068-1074
  • 24 Garg V, Kosmas C, Young PC, Togaru UK, Robbin MR. Computed tomography-guided percutaneous biopsy for vertebral osteomyelitis: a department’s experience. Neurosurg Focus 2014; 37 (02) E10