Conformation-Crooking CXCL4 to Unravel Autoimmune Heparin-Induced Thrombocytopenia

Rory R. Koenen

doi:10.1055/s-0040-1721774

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2021; 121(03): 258-260
DOI: 10.1055/s-0040-1721774

Invited Editorial Focus

Conformation-Crooking CXCL4 to Unravel Autoimmune Heparin-Induced Thrombocytopenia

Authors

Rory R. Koenen

¹Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands

²Institute for Cardiovascular Prevention, LMU Munich, Munich, Germany

Abstract

Full Text

References

References
1 Arepally GM, Ortel TL. Heparin-induced thrombocytopenia. Annu Rev Med 2010; 61: 77-90
2 Greinacher A. Heparin-induced thrombocytopenia. N Engl J Med 2015; 373 (19) 1883-1884
3 Vayne C, May MA, Bourguignon T. et al. Frequency and clinical impact of platelet factor 4-specific antibodies in patients undergoing extracorporeal membrane oxygenation. Thromb Haemost 2019; 119 (07) 1138-1146
4 Martel N, Lee J, Wells PS. Risk for heparin-induced thrombocytopenia with unfractionated and low-molecular-weight heparin thromboprophylaxis: a meta-analysis. Blood 2005; 106 (08) 2710-2715
5 Gruel Y, Vayne C, Rollin J. et al. Comparative analysis of a French Prospective Series of 144 Patients with Heparin-Induced Thrombocytopenia (FRIGTIH) and the literature. Thromb Haemost 2020; 120 (07) 1096-1107
6 Carlson DS, Bartholomew JR, Gomes MP, McCrae KR, Chaturvedi S. Outcomes of cardiovascular surgery utilizing heparin versus direct thrombin inhibitors in cardiopulmonary bypass in patients with previously diagnosed HIT. Thromb Haemost 2020; 120 (02) 300-305
7 Blanchet X, Cesarek K, Brandt J. et al. Inflammatory role and prognostic value of platelet chemokines in acute coronary syndrome. Thromb Haemost 2014; 112 (06) 1277-1287
8 Kreimann M, Brandt S, Krauel K. et al. Binding of anti-platelet factor 4/heparin antibodies depends on the thermodynamics of conformational changes in platelet factor 4. Blood 2014; 124 (15) 2442-2449
9 Cai Z, Yarovoi SV, Zhu Z. et al. Atomic description of the immune complex involved in heparin-induced thrombocytopenia. Nat Commun 2015; 6: 8277
10 Zheng Y, Yu M, Podd A. et al. Critical role for mouse marginal zone B cells in PF4/heparin antibody production. Blood 2013; 121 (17) 3484-3492
11 Hui M, Sheppard JI, Li N, Warkentin TE. Neutrophil and monocyte counts in heparin-induced thrombocytopenia. Thromb Haemost 2019; 119 (06) 941-951
12 Vayne C, Nguyen TH, Rollin J. et al. Characterization of new monoclonal PF4-specific antibodies as useful tools for studies on typical and autoimmune heparin-induced thrombocytopenia. Thromb Haemost 2020;
13 Greinacher A, Selleng K, Warkentin TE. Autoimmune heparin-induced thrombocytopenia. J Thromb Haemost 2017; 15 (11) 2099-2114