Abstract
Background Today, there is a need for new and independent additional advanced markers that can
predict the prognosis of meningioma patients, postoperatively. The present study aimed
to find out postoperative short-term prognostic markers in patients with meningioma
using their demographic data and routine blood biochemistry findings evaluated preoperatively.
Methods The Glasgow Coma Scale (GCS), and Glasgow Outcome Scale (GOS) scores of the patients
were recorded. Additionally, preoperatively obtained serum glucose, C-reactive protein
(CRP), sodium, potassium, creatinine, blood urea nitrogen, aspartate aminotransferase
(AST), alanine aminotransferase, and hemoglobin level values, platelet, leukocyte,
neutrophil, lymphocyte, eosinophil, basophil, and monocyte count results, erythrocyte
sedimentation rate (ESR), neutrophil-lymphocyte ratio, platelet-lymphocyte ratio (PLR)
and lymphocyte-monocyte ratio (LMR) values were evaluated.
Results In the present study, 23 operated patients with meningioma World Health Organization
(WHO) grade 1 (17 females, 6 males) were included. Correlation test results revealed
that the GCS score, platelet count, and serum potassium level values could directly
predict the short-term prognosis of these patients. Additionally, these test results
suggested that the lymphocyte, monocyte, and eosinophil count values, PLR, LMR, ESR,
serum glucose, CRP, and AST level values could be indirect markers in predicting the
short-term prognosis. However, likelihood ratio test results revealed that only monocyte
count value, LMR value, and serum CRP level value could be the markers for prediction
of the short-term prognosis.
Conclusion At the end of the present study, it was concluded that the monocyte count value,
LMR value, and serum CRP level value could be the best markers in predicting the short-term
prognosis of the operated meningioma patients.
Keywords
biochemistry - biomarker - meningioma - prognosis
