CC BY 4.0 · Semin Liver Dis 2021; 41(01): 050-066
DOI: 10.1055/s-0040-1722262
Review Article

Cellular Senescence in Liver Disease and Regeneration

Sofia Ferreira-Gonzalez
1  MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom
,
Daniel Rodrigo-Torres
1  MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom
,
Victoria L. Gadd
1  MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom
,
Stuart J. Forbes
1  MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom
› Author Affiliations
Funding This study was supported by Research Councils UK and Medical Research Council (MR/P016839/1, UKRMP, and MR/R015635/1).

Abstract

Cellular senescence is an irreversible cell cycle arrest implemented by the cell as a result of stressful insults. Characterized by phenotypic alterations, including secretome changes and genomic instability, senescence is capable of exerting both detrimental and beneficial processes. Accumulating evidence has shown that cellular senescence plays a relevant role in the occurrence and development of liver disease, as a mechanism to contain damage and promote regeneration, but also characterizing the onset and correlating with the extent of damage. The evidence of senescent mechanisms acting on the cell populations of the liver will be described including the role of markers to detect cellular senescence. Overall, this review intends to summarize the role of senescence in liver homeostasis, injury, disease, and regeneration.



Publication History

Publication Date:
09 February 2021 (online)

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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