J Neurol Surg B Skull Base 2021; 82(01): 020-026
DOI: 10.1055/s-0040-1722633
Typical Orbital Pathologies
Review Article

Typical Orbital Pathologies: Hemangioma

Christopher M. Low
1   Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, United States
,
Janalee K. Stokken
1   Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, United States
› Author Affiliations

Abstract

Orbital hemangiomas are the most common primary neoplasm of the orbit and manifest as two distinct pathologic entities: infantile hemangiomas and cavernous hemangiomas. In this article, both infantile and cavernous hemangiomas are reviewed, with special attention paid to the natural history, clinical presentation, and management teams and approaches involved. An example case of each type of hemangioma is presented along with pearls and tips a reader can take away after reading this article.

Financial Material & Support

Internal departmental funding was utilized without commercial sponsorship or support.




Publication History

Article published online:
19 January 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 Purohit BS, Vargas MI, Ailianou A. et al. Orbital tumours and tumour-like lesions: exploring the armamentarium of multiparametric imaging. Insights Imaging 2016; 7 (01) 43-68
  • 2 Li YC, McCahon E, Rowe NA, Martin PA, Wilcsek GA, Martin FJ. Successful treatment of infantile haemangiomas of the orbit with propranolol. Clin Exp Ophthalmol 2010; 38 (06) 554-559
  • 3 Haik BG, Karcioglu ZA, Gordon RA, Pechous BP. Capillary hemangioma (infantile periocular hemangioma). Surv Ophthalmol 1994; 38 (05) 399-426
  • 4 Osaki TH, Jakobiec FA, Mendoza PR, Lee Y, Fay AM. Immunohistochemical investigations of orbital infantile hemangiomas and adult encapsulated cavernous venous lesions (malformation versus hemangioma). Ophthal Plast Reconstr Surg 2013; 29 (03) 183-195
  • 5 Fay A, Nguyen J, Jakobiec FA, Meyer-Junghaenel L, Waner M. Propranolol for isolated orbital infantile hemangioma. Arch Ophthalmol 2010; 128 (02) 256-258
  • 6 Stigmar G, Crawford JS, Ward CM, Thomson HG. Ophthalmic sequelae of infantile hemangiomas of the eyelids and orbit. Am J Ophthalmol 1978; 85 (06) 806-813
  • 7 Fridman G, Grieser E, Hill R, Khuddus N, Bersani T, Slonim C. Propranolol for the treatment of orbital infantile hemangiomas. Ophthal Plast Reconstr Surg 2011; 27 (03) 190-194
  • 8 Drolet BA, Frommelt PC, Chamlin SL. et al. Initiation and use of propranolol for infantile hemangioma: report of a consensus conference. Pediatrics 2013; 131 (01) 128-140
  • 9 Léauté-Labrèze C, Dumas de la Roque E, Hubiche T, Boralevi F, Thambo J-B, Taïeb A. Propranolol for severe hemangiomas of infancy. N Engl J Med 2008; 358 (24) 2649-2651
  • 10 Ni N, Guo S, Langer P. Current concepts in the management of periocular infantile (capillary) hemangioma. Curr Opin Ophthalmol 2011; 22 (05) 419-425
  • 11 Guo S, Ni N. Topical treatment for capillary hemangioma of the eyelid using β-blocker solution. Arch Ophthalmol 2010; 128 (02) 255-256
  • 12 Ni N, Langer P, Wagner R, Guo S. Topical timolol for periocular hemangioma: report of further study. Arch Ophthalmol 2011; 129 (03) 377-379
  • 13 Harris GJ, Jakobiec FA. Cavernous hemangioma of the orbit. J Neurosurg 1979; 51 (02) 219-228
  • 14 Calandriello L, Grimaldi G, Petrone G. et al. Cavernous venous malformation (cavernous hemangioma) of the orbit: current concepts and a review of the literature. Surv Ophthalmol 2017; 62 (04) 393-403
  • 15 Rootman J, Heran MK, Graeb DA. Vascular malformations of the orbit: classification and the role of imaging in diagnosis and treatment strategies. Ophthal Plast Reconstr Surg 2014; 30 (02) 91-104
  • 16 Harris GJ. Orbital Society. Orbital vascular malformations: a consensus statement on terminology and its clinical implications. Am J Ophthalmol 1999; 127 (04) 453-455
  • 17 Jayaram A, Lissner GS, Cohen LM, Karagianis AG. Potential correlation between menopausal status and the clinical course of orbital cavernous hemangiomas. Ophthal Plast Reconstr Surg 2015; 31 (03) 187-190
  • 18 McNab AA, Selva D, Hardy TG, O'Donnell B. The anatomical location and laterality of orbital cavernous haemangiomas. Orbit 2014; 33 (05) 359-362
  • 19 Yan J, Wu Z. Cavernous hemangioma of the orbit: analysis of 214 cases. Orbit 2004; 23 (01) 33-40
  • 20 Bleier BS, Castelnuovo P, Battaglia P. et al. Endoscopic endonasal orbital cavernous hemangioma resection: global experience in techniques and outcomes. Int Forum Allergy Rhinol 2016; 6 (02) 156-161
  • 21 McCannel CA, Hoenig J, Umlas J, Woog JJ, Newman AN, Bateman JB. Orbital lesions in the blue rubber bleb nevus syndrome. Ophthalmology 1996; 103 (06) 933-936
  • 22 Thorn-Kany M, Arrué P, Delisle MB, Lacroix F, Lagarrigue J, Manelfe C. Cavernous hemangiomas of the orbit: MR imaging. J Neuroradiol 1999; 26 (02) 79-86
  • 23 Ansari SA, Mafee MF. Orbital cavernous hemangioma: role of imaging. Neuroimaging Clin N Am 2005; 15 (01) 137-158
  • 24 El Rassi E, Adappa ND, Battaglia P. et al. Development of the international orbital Cavernous Hemangioma Exclusively Endonasal Resection (CHEER) staging system. Int Forum Allergy Rhinol 2014; 9 (07) 804-812
  • 25 Chhabra N, Wu AW, Fay A, Metson R. Endoscopic resection of orbital hemangiomas. Int Forum Allergy Rhinol 2014; 4 (03) 251-255
  • 26 Miyake MM, Bleier BS. Endoscopic approach to primary orbital tumors. Curr Otorhinolaryngol Rep 2016; 4 (04) 280-285
  • 27 Marcellino CR, Peris-Celda M, Link MJ, Stokken JK. Endoscopic endonasal resection of orbital apex cavernous hemangioma: 2-dimensional operative video. Oper Neurosurg (Hagerstown) 2019; 16 (05) E144-E145
  • 28 Rootman DB, Rootman J, Gregory S, Feldman KA, Ma R. Stereotactic fractionated radiotherapy for cavernous venous malformations (hemangioma) of the orbit. Ophthal Plast Reconstr Surg 2012; 28 (02) 96-102
  • 29 Leber KA, Berglöff J, Pendl G. Dose-response tolerance of the visual pathways and cranial nerves of the cavernous sinus to stereotactic radiosurgery. J Neurosurg 1998; 88 (01) 43-50