STAT3-Ser/Hes3 Signaling: A New Molecular Component of the Neuroendocrine System?

P. Nikolakopoulou; S. W. Poser; J. Masjkur; M. Fernandez Rubin de Celis; L. Toutouna; C. L. Andoniadou; R. D. McKay; G. Chrousos; M. Ehrhart-Bornstein; S. R. Bornstein; A. Androutsellis-Theotokis

doi:10.1055/s-0041-111699

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2016; 48(02): 77-82
DOI: 10.1055/s-0041-111699

Review

STAT3-Ser/Hes3 Signaling: A New Molecular Component of the Neuroendocrine System?

Authors

P. Nikolakopoulou

¹Department of Internal Medicine III, Technische Universität Dresden, Dresden, Germany
S. W. Poser

¹Department of Internal Medicine III, Technische Universität Dresden, Dresden, Germany
J. Masjkur

¹Department of Internal Medicine III, Technische Universität Dresden, Dresden, Germany
M. Fernandez Rubin de Celis

¹Department of Internal Medicine III, Technische Universität Dresden, Dresden, Germany
L. Toutouna

¹Department of Internal Medicine III, Technische Universität Dresden, Dresden, Germany
C. L. Andoniadou

²Department of Craniofacial Development and Stem Cell Biology, King’s College London, UK
R. D. McKay

³Lieber Institute for Brain Development, Baltimore, USA
G. Chrousos

⁴1st Department of Pediatrics, University of Athens Medical School, Athens, Aghia Sophia Children’s Hospital, Athens, Greece
M. Ehrhart-Bornstein

¹Department of Internal Medicine III, Technische Universität Dresden, Dresden, Germany
S. R. Bornstein

¹Department of Internal Medicine III, Technische Universität Dresden, Dresden, Germany
A. Androutsellis-Theotokis

¹Department of Internal Medicine III, Technische Universität Dresden, Dresden, Germany

⁵Center for Regenerative Therapies Dresden, Dresden, Germany

⁶Department of Stem Cell Biology, Centre for Biomolecular Sciences, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, UK

Abstract

The endocrine system involves communication among different tissues in distinct organs, including the pancreas and components of the Hypothalamic-Pituitary-Adrenal Axis. The molecular mechanisms underlying these complex interactions are a subject of intense study as they may hold clues for the progression and treatment of a variety of metabolic and degenerative diseases. A plethora of signaling pathways, activated by hormones and other endocrine factors have been implicated in this communication. Recent advances in the stem cell field introduce a new level of complexity: adult progenitor cells appear to utilize distinct signaling pathways than the more mature cells in the tissue they co-reside. It is therefore important to elucidate the signal transduction requirements of adult progenitor cells in addition to those of mature cells. Recent evidence suggests that a common non-canonical signaling pathway regulates adult progenitors in several different tissues, rendering it as a potentially valuable starting point to explore their biology. The STAT3-Ser/Hes3 Signaling Axis was first identified as a major regulator of neural stem cells and, subsequently, cancer stem cells. In the endocrine/neuroendocrine system, this pathway operates on several levels, regulating other types of plastic cells: (a) it regulates pancreatic islet cell function and insulin release; (b) insulin in turn activates the pathway in broadly distributed neural progenitors and possibly also hypothalamic tanycytes, cells with important roles in the control of the adrenal gland; (c) adrenal progenitors themselves operate this pathway. The STAT3-Ser/Hes3 Signaling Axis therefore deserves additional research in the context of endocrinology.

Key words

STAT3 - Hes3 - stem cells

Full Text

References

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