Int J Angiol 2024; 33(01): 057-061
DOI: 10.1055/s-0041-1723945
Case Report

Sinus Node Dysfunction and Pulmonary Hypertension—“Double Trouble” with Lithium Therapy

1   Department of Cardiology, King George's Medical University, Lucknow, Uttar Pradesh, India
1   Department of Cardiology, King George's Medical University, Lucknow, Uttar Pradesh, India
Rishi Sethi
1   Department of Cardiology, King George's Medical University, Lucknow, Uttar Pradesh, India
1   Department of Cardiology, King George's Medical University, Lucknow, Uttar Pradesh, India
› Author Affiliations


Lithium is considered a gold standard drug for the management of bipolar disorder and is a widely used mood-stabilizing drug in psychiatry practice. However, its side effects are of important concern. The narrow therapeutic index of lithium predispose to its toxicity/side effects, but various case reports and research has shown that adverse drug reactions can occur even in the therapeutic range. We present the case of a 56-year-old woman with no history of cardiac illness presenting with tachycardia-bradycardia syndrome along with moderate pulmonary hypertension. Patients recovered to sinus rhythm after withholding lithium therapy for 1 week while her mean pulmonary artery pressure remained the same at day 10 of drug withdrawal.

Publication History

Article published online:
21 September 2021

© 2021. International College of Angiology. This article is published by Thieme.

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