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CC BY 4.0 · Journal of Child Science 2021; 11(01): e60-e64
DOI: 10.1055/s-0041-1724033
Original Article

Investigation of Tissue Transglutaminase Antibody Normalization in Response to Gluten-Free Diet in Children with Celiac Disease

Mohsen Pour Ebrahimi
1   Pediatric Gastroenterology and Hepatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
,
Hosein Alimadadi
1   Pediatric Gastroenterology and Hepatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
,
Mehri Najafi
1   Pediatric Gastroenterology and Hepatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
,
Mohammad Vasei
2   Cell Therapies Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Shariati Hospital, Tehran, Iran
,
Parisa Rahmani 
1   Pediatric Gastroenterology and Hepatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
› Author Affiliations Funding None.
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Abstract

A very limited amount of data are available regarding the follow-up of celiac disease (CD) treatment in Iran. The aim of this study is to investigate antitissue transglutaminase (atTG) normalization interval and the associated factors in CD patients. This retrospective study included CD patients enrolled in Children's Medical Center, Tehran University of Medical Sciences. The initial atTG titer and histological evaluation (with Marsh grade ≥2) were recorded. The atTG titer was assessed in each follow-up until the time of normalization where children were strictly on gluten-free diet. The age at the time of diagnosis, gender, Marsh grade at the time of diagnosis, other comorbidities, and family history of CD patients were recorded to determine the association of these factors with antibody normalization interval. In total, 71 patients were recruited in the study of which 34 (47.89%) subjects had atTG level below 20 U/mL at the average interval of 31.36 ( ±  2.89) months (95% confidence interval: 25.7–37.02). There was no significant difference between the antibody normalization interval and different age ranges and Marsh grade. Cox regression demonstrated that gender, age ranges, Marsh grade, positive family history of CD, and the presence of comorbidities did not significantly predict longer antibody normalization interval.

Keywords

celiac disease - antitissue transglutaminase - pediatric - children - antibody normalization - marsh grade

Note

All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.


Authors' Contributions

M.P.E. and H.A. conceptualized and designed the study, drafted the initial manuscript, and reviewed and revised the manuscript. P.R. designed the data collection instruments, collected data, performed the initial analyses, and reviewed and revised the manuscript. M.N. and M.V. coordinated and supervised data collection, and critically reviewed the manuscript for important intellectual content.




Publication History

Received: 21 October 2020

Accepted: 25 December 2020

Article published online:
03 March 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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