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CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol 2022; 26(03): e380-e389
DOI: 10.1055/s-0041-1726048
Original Research

Frequency-Following Response and Auditory Behavior in Children with Prenatal Exposure to the Zika Virus

Laís Cristine Delgado da Hora 
1   Department of Speech, Language and Audiology, Universidade Federal de Pernambuco, Recife, PE, Brazil
,
Lilian Ferreira Muniz 
1   Department of Speech, Language and Audiology, Universidade Federal de Pernambuco, Recife, PE, Brazil
,
Silvana Maria Sobral Griz 
1   Department of Speech, Language and Audiology, Universidade Federal de Pernambuco, Recife, PE, Brazil
,
Jéssica Dayane da Silva 
2   Graduate Program in Human Communication Health, Universidade Federal de Pernambuco, Recife, PE, Brazil
,
Diana Babini Lapa de Albuquerque Britto 
1   Department of Speech, Language and Audiology, Universidade Federal de Pernambuco, Recife, PE, Brazil
,
Leonardo Gleygson Angelo Venâncio 
2   Graduate Program in Human Communication Health, Universidade Federal de Pernambuco, Recife, PE, Brazil
,
Demócrito de Barros Miranda Filho 
3   Medical Sciences College, Universidade de Pernambuco, Recife, PE, Brazil
,
Mariana de Carvalho Leal 
4   Department of Surgery, Universidade Federal de Pernambuco, Recife, PE, Brazil
› Author Affiliations Funding This study was funded by the Brazilian’s National Council for Scientific and Technological Development (CNPq - Universal 01/2016-420108/2016-5) and had also the support of Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) - Finance code 001.
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Abstract

Introduction Prenatal exposure to the Zika virus can impair neurodevelopment and cause auditory damage.

Objective To analyze the frequency-following response (FFR) and the auditory behavior (with the LittlEars ® questionnaire) of children with and without prenatal exposure to Zika virus infection.

Methods A total of 30 children participated in the present study, divided into 3 groups: 10 children with microcephaly and prenatal exposure to the Zika virus; 10 normocephalic children with prenatal exposure to the Zika virus; and 10 children with no evidence of prenatal exposure to the virus. The FFR test was performed with the /da/ syllable. The LittlEars ® questionnaire was used with parents/guardians.

Results For the FFR measurements, there was no difference between the groups. The children with exposure to the Zika virus presented a final score in the questionnaire below what is expected from children with normal hearing. A significant difference was observed for the final, semantic, and expressive scores between the group with microcephaly and the other groups. A strong negative correlation was seen between the LittlEars ® questionnaire final score and the FFR measurements for the group with microcephaly when compared with the other groups.

Conclusion Children exposed to the Zika virus, with and without microcephaly, presented FFR patterns similar to what was seen in children with no evidence of virus exposure. However, they showed signs of immature auditory behavior, suggesting auditory development delay.

Keywords

zika virus - microcephaly - surveys and questionnaires - frequency-following response - speech-evoked auditory brainstem response - evoked potentials - auditory brain stem


Publication History

Received: 10 August 2020

Accepted: 01 December 2020

Article published online:
03 November 2021

© 2021. Fundação Otorrinolaringologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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