Evaluation of Hormonal Influence in Patients with Fractures Attributed to Osteoporosis^[*]

Abstract

Objective The present study aims to evaluate the influence of hormonal levels of vitamin D, calcitonin, testosterone, estradiol, and parathyroid in patients with fractures attributed to osteoporosis when compared with young patients with fractures resulting from high-impact accidents.

Methods Blood samples were collected from 30 elderly patients with osteoporosis-attributed fractures (T-score ≤ -2.5) (osteoporotic group), and from 30 young patients with fractures resulting from high-impact accidents (control group). Measurement of 1,25-hydroxyvitamin D (Kit Diasorin, Saluggia, Italy), calcitonin (Kit Siemens, Tarrytown, NY, USA), testosterone, estradiol, and parathyroid hormone (Kit Beckman Couter, Indianapolis, IN, United States) was performed using a chemiluminescence technique. Data were inserted into a Microsoft Excel (Microsoft Corp., Armonk, WA, USA) spreadsheet and analyzed using Statview statistical software. Results showing non-normal distribution were analyzed with nonparametric methods. The Mann-Whitney test was applied for group comparison, and a Spearman test correlated hormonal levels. Statistical significance was set at p < 0.05. All analyzes compared gender and subjects with and without osteoporosis.

Results Women with osteoporosis had significantly lower levels of estradiol and vitamin D (p = 0.047 and p = 0.0275, respectively). Men with osteoporosis presented significantly higher levels of parathyroid hormone (p = 0.0065). There was no significant difference in testosterone and calcitonin levels.

Conclusion Osteoporosis patients presented gender-related hormonal differences. Women had significantly lower levels of estradiol and vitamin D, whereas men had significantly higher parathyroid hormone levels, apparently impacting the disease.

Keywords

osteoporosis - hormones - estradiol - calcitonin - parathyroid hormone

Authors contributions

All authors contributed to the conception and design of the study. The study was designed by Rodrigues V. e Rodrigues D. B. R. Gaia, L. F. P., Sousa F. F. A., Favaro, P. I. and Malheiros-Souza D. collected the material, prepared the database, and performed the statistical analyzes. Malheiros-Souza D. and Rodrigues D. B. R. wrote the manuscript and revised it. Rodrigues V. revised the manuscript.

^* Study developed at the Immunology Laboratory, Department of Biological Sciences, Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil.

Publication History

Received: 05 August 2020

Accepted: 01 December 2020

Article published online:
27 August 2021

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