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CC BY-NC-ND 4.0 · Journal of Clinical Interventional Radiology ISVIR 2022; 6(01): 23-27
DOI: 10.1055/s-0041-1729469
Original Article

Opioid and/or Psychotropic Use Increases Intraprocedural Sedation Drug Requirements

Sreeja Sanampudi
1   Department of Radiology, University of Kentucky College of Medicine, Lexington, Kentucky, United States
,
Ravi Jayavarapu
2   Department of Radiology, University of Kentucky, Lexington, Kentucky, United States
,
Trae Brooks 
1   Department of Radiology, University of Kentucky College of Medicine, Lexington, Kentucky, United States
,
Driss Raissi
3   Division of Interventional Radiology, Department of Radiology, University of Kentucky, Lexington, Kentucky, United States
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Abstract

Objectives Acute pain management in opioid users can be challenging in the perioperative period. This study focuses on whether use of opioids increases sedation medication requirements in patients undergoing port placement under moderate sedation.

Materials and Methods A retrospective review was performed on all patients undergoing port placement between June 1, 2017, and June 30, 2019. Exclusion criteria included receiving general anesthesia, no sedation, and errors in data entry. Data collection included demographics, use of opioids, benzodiazepines, antidepressants, tobacco, alcohol, and sedation data.

Results Opioid, benzodiazepine, and selective serotonin reuptake inhibitors (SSRIs)/serotonin-norepinephrine reuptake inhibitors (SNRIs) use was significantly associated with higher sedation drug dose requirements. Patients using opioids required 10.5% higher doses of midazolam compared with nonusers. Benzodiazepine users required 16.3% additional dosage of midazolam than nonusers. Finally, patients on SSRIs/SNRIs medications required 11.8% higher midazolam dosing when compared with nonusers.

Conclusion Anticipating higher needs of sedation medications during procedures in patients with history of psychotropic agents use can allow for more effective sedation and patient satisfaction. More patient and provider awareness is needed on this topic, as health care policy is moving toward value-based healthcare, with patient satisfaction surveys being one of its indicators.

Keywords

sedation - opioids - benzodiazepines


Publication History

Article published online:
18 May 2021

© 2021. Indian Society of Vascular and Interventional Radiology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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