CC BY 4.0 · ACI open 2021; 05(02): e54-e58
DOI: 10.1055/s-0041-1729981
Invited Editorial

Facilitating Genetics Aware Clinical Decision Support: Putting the eMERGE Infrastructure into Practice

Casey Overby Taylor
1   Departments of Medicine and Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States
2   Geisinger Health System, Genomic Medicine Institute, Danville, Pennsylvania, United States
Luke V. Rasmussen
3   Department of Preventive Medicine, Northwestern University, Chicago, Illinois, United States
Laura J. Rasmussen-Torvik
3   Department of Preventive Medicine, Northwestern University, Chicago, Illinois, United States
Cynthia A. Prows
4   Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
David A. Dorr
5   Departments of Medical Informatics and Clinical Epidemiology and Medicine, Oregon Health & Science University, Portland, Oregon, United States
Lipika Samal
6   Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States
Samuel Aronson
7   Partners Personalized Medicine, Partners HealthCare, Cambridge, Massachusetts, United States
› Author Affiliations
Funding This study received its financial support from U.S. Department of Health and Human Services, National Institutes of Health, National Human Genome Research Institute (grant numbers: U01HG6379, U01HG8679, U01HG8676, and U01HG8673) and Cincinnati Children's Hospital Medical Center (grant: U01HG8666).


This editorial provides context for a series of published case reports in ACI Open by summarizing activities and outputs of joint electronic health record integration and pharmacogenomics workgroups in the NIH-funded electronic Medical Records and Genomics (eMERGE) Network. A case report is a useful tool to describe the range of capabilities that an IT infrastructure or a particular technology must support. The activities we describe have informed infrastructure requirements used during eMERGE phase III, provided a venue to share experiences and ask questions among other eMERGE sites, summarized potential hazards that might be encountered for specific clinical decision support (CDS) implementation scenarios, and provided a simple framework that captured progress toward implementing CDS at eMERGE sites in a consistent format.

Publication History

Received: 30 June 2020

Accepted: 29 January 2021

Article published online:
06 July 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (

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