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CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol 2022; 26(02): e208-e212
DOI: 10.1055/s-0041-1730301
Original Article

Is There a Difference between the Preoperative and Postoperative Serum Levels of Interleukin-6 and Tumor Necrosis Factor-α in Children Submitted to Adenotonsillectomy?

Jose Neto Ribeiro de Souza 
1   Department of Otorhinolaryngology, Universidade Federal de Goiás, Goiânia, GO, Brazil
,
Fernanda de Oliveira Feitosa de Castro 
2   Institute of Tropical Pathology and Public Health, Universidade Federal de Goiás, Goiânia, GO, Brazil
,
Camila Lemes de Souza 
2   Institute of Tropical Pathology and Public Health, Universidade Federal de Goiás, Goiânia, GO, Brazil
,
Mikhael Romanholo El Cheikh 
1   Department of Otorhinolaryngology, Universidade Federal de Goiás, Goiânia, GO, Brazil
,
Hugo Valter Lisboa Ramos 
3   Otorhinolaryngology, Centro de Reabilitação e Readaptação Dr. Henrique Santilo (CRER), Goiânia, GO, Brazil
,
Simone Gonçalves da Fonseca 
2   Institute of Tropical Pathology and Public Health, Universidade Federal de Goiás, Goiânia, GO, Brazil
,
Claudiney Candido Costa 
3   Otorhinolaryngology, Centro de Reabilitação e Readaptação Dr. Henrique Santilo (CRER), Goiânia, GO, Brazil
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Abstract

Introduction Palatine and pharyngeal tonsils are the first line of defense against pathogens. Clinically, two alterations may require surgical removal of the tonsils: hypertrophy and recurrent tonsillitis. The two conditions probably result from a dysfunction of the immune system.

Objective To evaluate possible differences in the plasma levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) in patients submitted to adenotonsillectomy.

Methods Prospective, longitudinal study with 25 children undergoing adenotonsillectomy separated into 3 different groups: recurrent tonsillitis (RT), composed of 7 patients; recurrent hypertrophy tonsillitis (RTTH), with 8 patients; and the tonsillar hypertrophy (TH) group, with 10 patients. Ten healthy control children (SD) were also included in the study. Peripheral blood was collected, and plasma was separated to measure the levels of TNF-α, IL-6, and IL-10. The Mann-Whitney test was used for statistical analysis.

Results The plasma level of IL-6 was higher in the RT (p = 0.0394) and TH (p = 0.0009) groups, compared with the control group. The TH group also had higher levels of IL-6 than the RT group (p = 0.039). The IL-6/IL-10 ratio was higher in the RT (p = 0.029) and TH (p = 0.0005) groups compared with the control group. Between the RT and RTTH groups, the IL-6/IL-10 ratio was higher in the RT group, with a statistically significant difference (p = 0.0091).

Conclusion Patients with a history of chronic tonsillitis had higher levels of IL-6, compared with the control group.

Keywords

chronic tonsillitis - tonsillar hypertrophy - adenotonsillectomy - cytokines


Publikationsverlauf

Eingereicht: 24. August 2020

Angenommen: 20. Dezember 2020

Artikel online veröffentlicht:
19. August 2021

© 2021. Fundação Otorrinolaringologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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