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CC BY-NC-ND 4.0 · J Lab Physicians 2021; 13(02): 139-143
DOI: 10.1055/s-0041-1730751
Original Article

Low Plasma Ascorbate Levels in Type 2 Diabetic Patients With Adequate Dietary Vitamin C

Abhishek Bansal
1   Department of Biochemistry, KLE Academy of Higher Education and Research (KAHER), J.N. Medical College, Belagavi, Karnataka, India
,
Chetana P. Hadimani 
1   Department of Biochemistry, KLE Academy of Higher Education and Research (KAHER), J.N. Medical College, Belagavi, Karnataka, India
› Author Affiliations Funding Source Not applicable.
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Abstract

Background Dietary intake of antioxidative vitamin C plays a protective role in the prevention of oxidative damage in diabetics, demanding increased requirement of vitamin C. Hyperglycemia results in impaired uptake of vitamin C in the cell. The present study was conducted to compare the plasma ascorbate levels in type 2 diabetic patients and controls consuming adequate dietary vitamin C.

Methodology Fifty consented type 2 diabetes mellitus (T2DM) patients who were on treatment with oral hypoglycemic drugs and consuming adequate vitamin C in diet were taken in the study and 50 healthy controls equitably matched for age, gender between 40 and 70 years, and dietary intake of vitamin C were compared. Dietary intake of vitamin C was estimated by a food frequency questionnaire. Subjects consuming more than 35 mg/d of vitamin C were included in the study. Fasting blood sugar was estimated by glucose oxidase and peroxidase method and estimation of ascorbic acid was done by using 2, 4 dinitro phenyl hydrazine method.

Result The mean ± standard deviation levels of plasma ascorbate levels in diabetic subjects were 0.22 ± 0.12 mg/dL, which were significantly lower as compared with controls with plasma ascorbate level of 0.47 ± 0.15 mg/dL. In diabetic subjects, insignificant positive correlation was observed between these parameters with r-value 0.168 and p-value 0.245.

Conclusion This study concludes that even with the recommended dietary intake of vitamin C low plasma ascorbate levels were found among T2DM patients, which necessitates increased demand and dietary advice to diabetic patients on consuming foods rich in vitamin C more than the recommended daily allowance.

Keywords

type 2 diabetes mellitus - dietary vitamin C - plasma ascorbate - FBS

Supplementary Material



Publication History

Article published online:
16 June 2021

© 2021. The Indian Association of Laboratory Physicians. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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