Cerebral Metabolic Crisis in Pediatric Cerebral Malaria

Nicole F. O'Brien; Karen Chetcuti; Yudy Fonseca; Lorenna Vidal; Prashant Raghavan; Douglas G. Postels; Yamikani Chimalizeni; Stephen Ray; Karl B. Seydel; Terrie E. Taylor

doi:10.1055/s-0041-1732444

Journal of Pediatric Intensive Care, Table of Contents

J Pediatr Intensive Care 2023; 12(04): 278-288
DOI: 10.1055/s-0041-1732444

Original Article

Cerebral Metabolic Crisis in Pediatric Cerebral Malaria

Authors

Nicole F. O'Brien

¹Division of Critical Care Medicine, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, United States
Karen Chetcuti

²Department of Radiology, College of Medicine, Chichiri, Blantyre, Malawi
Yudy Fonseca

³Division of Critical Care Medicine, Department of Pediatrics, University of Maryland Medical Center, University of Maryland School of Medicine, Baltimore, Maryland, United States
Lorenna Vidal

⁴Division of Neuroradiology, Department of Radiology Children's Hospital of Philadelphia, Clinical Instructor at Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States
Prashant Raghavan

⁵Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States
Douglas G. Postels

⁶Department of Neurology, George Washington University/Children's National Medical Center, Washington, District of Columbia, United States
Yamikani Chimalizeni

⁷Department of Pediatrics and Child Health, University of Malawi, Malawi College of Medicine, Chichiri, Blantyre, Malawi
Stephen Ray

⁸Department of Paediatric, Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi
Karl B. Seydel

⁹Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, United States

¹⁰Blantyre Malaria Project, Blantyre, Malawi
Terrie E. Taylor

⁹Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, United States

Abstract

Cerebral metabolic energy crisis (CMEC), often defined as a cerebrospinal fluid (CSF) lactate: pyruvate ratio (LPR) >40, occurs in various diseases and is associated with poor neurologic outcomes. Cerebral malaria (CM) causes significant mortality and neurodisability in children worldwide. Multiple factors that could lead to CMEC are plausible in these patients, but its frequency has not been explored. Fifty-three children with CM were enrolled and underwent analysis of CSF lactate and pyruvate levels. All 53 patients met criteria for a CMEC (median CSF LPR of 72.9 [interquartile range [IQR]: 58.5–93.3]). Half of children met criteria for an ischemic CMEC (median LPR of 85 [IQR: 73–184]) and half met criteria for a nonischemic CMEC (median LPR of 60 [IQR: 54–79]. Children also underwent transcranial doppler ultrasound investigation. Cerebral blood flow velocities were more likely to meet diagnostic criteria for low flow (<2 standard deviation from normal) or vasospasm in children with an ischemic CMEC (73%) than in children with a nonischemic CMEC (20%, p = 0.04). Children with an ischemic CMEC had poorer outcomes (pediatric cerebral performance category of 3–6) than those with a nonischemic CMEC (46 vs. 22%, p = 0.03). CMEC was ubiquitous in this patient population and the processes underlying the two subtypes (ischemic and nonischemic) may represent targets for future adjunctive therapies.

Keywords

cerebral malaria - cerebral blood flow - brain blood flow - brain disorders - metabolic - Doppler sonography - transcranial

Full Text

References

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