Z Gastroenterol 2021; 59(08): e195-e196
DOI: 10.1055/s-0041-1733581
Von der Pankreatitis zum Karzinom: Klinische Aspekte
Freitag, 17. September 2021, 11:45-13:05 Uhr, Saal 5
Pankreas

Chronic Pancreatitis Prognosis Score (COPPS): results from an international prospective multicenter validation study

A Garbe
1   LMU University Hospital, Department of Medicine II, Munich, Deutschland
,
Mahajan UM
1   LMU University Hospital, Department of Medicine II, Munich, Deutschland
,
T Kohlmann
2   University Medicine Greifswald, Institute of Community Medicine, Greifswald, Deutschland
,
E Goni
1   LMU University Hospital, Department of Medicine II, Munich, Deutschland
,
C Budde
3   University Medicine Greifswald, Department of Medicine A, Greifswald, Deutschland
,
F Gorelick
4   Yale School of Medicine, Department of Internal Medicine, New Haven, Vereinigte Staaten von Amerika
,
T Muniraj
4   Yale School of Medicine, Department of Internal Medicine, New Haven, Vereinigte Staaten von Amerika
,
E Martinez-Moneo
5   Cruces University Hospital, Gastroenterology Department, Vizcaya, Spanien
,
T Shimosegawa
6   Tohoku University Graduate School of Medicine, Division of Gastroenterology, Sendai, Japan
,
A Masamune
6   Tohoku University Graduate School of Medicine, Division of Gastroenterology, Sendai, Japan
,
C Forsmark
7   University of Florida, Division of Gastroenterology, Hepatology, and Nutrition, Gainsville, Vereinigte Staaten von Amerika
,
P Garg
8   All India Institute Of Medical Sciences, Department of Gastroenterology, New Delhi, Indien
,
A Gomes
9   Hospital Prof. Dr. Fernando Fonseca, Servico de Cirurgia B, Amadora, Portugal
,
S Stigliano
10   II Medical School, University La Sapienza, Digestive and Liver Disease Unit, Rome, Italien
,
M Faghih
11   Johns Hopkins Medical Institutions, Division of Gastroenterology, Baltimore, Vereinigte Staaten von Amerika
,
V Singh
11   Johns Hopkins Medical Institutions, Division of Gastroenterology, Baltimore, Vereinigte Staaten von Amerika
,
U Bughio
12   Asian Institute of Medical Sciences, Hyderabad, Pakistan
,
Marchi G De
13   University of Verona, Pancreas Institute, Department of Medicine, Veron, Italien
,
L Frulloni
13   University of Verona, Pancreas Institute, Department of Medicine, Veron, Italien
,
A Mendoza-Ladd
14   Texas Tech University Health Sciences Center, Gastroenterology, El Paso, Vereinigte Staaten von Amerika
,
D Conwell
15   The Ohio State University Wexner Medical Center, Section of Pancreatic Disorders, Division of Gastroenterology, Hepatology, and Nutrition, Columbus, Vereinigte Staaten von Amerika
,
MM Lerch
3   University Medicine Greifswald, Department of Medicine A, Greifswald, Deutschland
16   LMU University Hospital, Munich, Deutschland
,
J Mayerle
1   LMU University Hospital, Department of Medicine II, Munich, Deutschland
,
G Beyer
1   LMU University Hospital, Department of Medicine II, Munich, Deutschland
› Author Affiliations
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Background We recently developed a multivariate scoring system for chronic pancreatitis using BMI, pain, CRP, platelets and HbA1c. COPPS allowed objective monitoring of disease severity, determining risk for readmission to hospital and length of hospital stay in a prospective development cohort and retrospective validation cohort, recruited in Germany and Denmark ([1]).

Aim and Methods This is a prospective multicenter, international observational cohort study to validate the prognostic value of COPPS. We screened patients between 04/2016 and 09/2019 with chronic pancreatitis at 15 international centers for participation in an observational study. At baseline COPPS, demographics and etiological factors were recorded. Patients were followed for 12 months. The primary end-point was readmissions to hospital. The study was approved by IRB of all centers.

Results Of 546 screened patients, 420 met all inclusion criteria and complete follow-up data for analysis was available. The median age at diagnosis was 47.4 years (±19.420 SD), including 118 (28.1 %) women. Ninety-nine (23.6%) were recruited from centers in the United States, 76 (18.1%) from Asia and 245 (58.3%) from Europe. Alcohol was the most common etiology (50 %). Mean COPPS was 8.2 points (SD ±1.90), with 84 (20.0 %), 233 (55.5 %) and 103 (24.5 %) patients in the respective COPPS category A, B, C. COPPS category A, B or C correlated with both primary endpoints, number of hospital admissions (adjusted r2 .031, p< 0.001) and number of days spent in hospital (adjusted r2 .013, p< 0.01) within one year from admission.

Conclusion Chronic Pancreatitis Prognosis Score (COPPS) reliably predicts the risk for readmission in a large, prospective, international cohort of patients with chronic pancreatitis. This supports the potential value of COPPS as a reliable tool for severity grading of chronic pancreatitis in clinical routine and as a potential surrogate endpoint in clinical studies.



Publication History

Article published online:
07 September 2021

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  • 1 Beyer G, Mahajan UM, Budde C, Bulla TJ, Kohlmann T, Kuhlmann L. , et al. Development and Validation of a Chronic Pancreatitis Prognosis Score in 2 Independent Cohorts. Gastroenterology. 2017; 153 (06) 1544-54.e2.
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