Semin Respir Crit Care Med 2021; 42(05): 706-716
DOI: 10.1055/s-0041-1733899
Review Article

Evidence for the Application of Sepsis Bundles in 2021

Erika P. Plata-Menchaca
1  Shock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain
2  Department of Intensive Care, Hospital Clínic de Barcelona, Barcelona, Spain
,
Juan Carlos Ruiz-Rodríguez
1  Shock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain
3  Department of Intensive Care, Vall d'Hebron Hospital Universitari, Vall d'Hebron, Barcelona, Spain
4  Department of Medicine, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
,
Ricard Ferrer
1  Shock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain
3  Department of Intensive Care, Vall d'Hebron Hospital Universitari, Vall d'Hebron, Barcelona, Spain
4  Department of Medicine, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
› Author Affiliations

Abstract

Sepsis represents a severe condition that predisposes patients to a high risk of death if its progression is not ended. As with other time-dependent conditions, the performance of determinant interventions has led to significant survival benefits and quality-of-care improvements in acute emergency care. Thus, the initial interventions in sepsis are a cornerstone for prognosis in most patients. Even though the evidence supporting the hour-1 bundle is perfectible, real-life application of thoughtful and organized sepsis care has improved survival and quality of care in settings promoting compliance to evidence-based treatments. Current evidence for implementing the Surviving Sepsis Campaign bundles for early sepsis management is moving forward to better approaches as more substantial evidence evolves.



Publication History

Publication Date:
20 September 2021 (online)

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