Homeopathy 2022; 111(03): 226-231
DOI: 10.1055/s-0041-1734027
Hypothesis

Dengue Shock Syndrome: Its Similarity with Anaphylaxis and with the Homeopathic Medicine Apis mellifica (European Honeybee)

1   Berkeley, California, United States
› Institutsangaben

Abstract

Dengue, with four viral serotypes, causes epidemics in tropical and sub-tropical regions. Allopathic antiviral therapies and a vaccine of general use are lacking. The homeopathic medicine Apis mellifica, advised in anaphylaxis from honeybee sting, is proposed to address the life-threatening dengue shock syndrome, which develops from dengue hemorrhagic fever and has features of anaphylaxis. In both dengue and anaphylaxis, immunoglobulin E activates, and released vasoactive mediators (importantly histamine, tryptase and platelet-activating factor) cause, a vascular permeability enabling shock. In dengue, another mechanism, namely antibody-dependent enhancement, due to secondary infection with a heterologous dengue serotype, is associated with release of vasoactive mediators. The homeopathic medicine Apis mellifica indicates plasma leak, shock, and the serous effusion that is noted in dengue patients, and is a suggested prophylactic and therapeutic medicine for dengue shock syndrome.



Publikationsverlauf

Eingereicht: 30. April 2021

Angenommen: 30. Juni 2021

Artikel online veröffentlicht:
08. November 2021

© 2021. Faculty of Homeopathy. This article is published by Thieme.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 Bhatt S, Gething PW, Brady OJ. et al. The global distribution and burden of dengue. Nature 2013; 496: 504-507
  • 2 Gubler DJ. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev 1998; 11: 480-496
  • 3 Marino R. Homeopathy and collective health: the case of dengue epidemics. Int J High Dilution Res 2008; 7: 179-185
  • 4 Weaver SC, Charlier C, Vasilakis N, Lecuit M. Zika, chikungunya, and other emerging vector-borne viral diseases. Annu Rev Med 2018; 69: 395-408
  • 5 Tan VPK, Ngim CF, Lee EZ. et al. The association between obesity and dengue virus (DENV) infection in hospitalised patients. PLoS One 2018; 13: e0200698
  • 6 Shyamali NLA, Mahapatuna SD, Gomes L, Wijewickrama A, Ogg GS, Malavige GN. Risk factors for elevated serum lipopolysaccharide in acute dengue and association with clinical disease severity. Trop Med Infect Dis 2020; 5: 170
  • 7 Wilder-Smith A. Dengue vaccine development: status and future. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2020; 63: 40-44
  • 8 Mahesh S, Mahesh M, Vithoulkas G. Could homeopathy become an alternative therapy in dengue fever? An example of 10 case studies. J Med Life 2018; 11: 75-82
  • 9 Nayak D, Chadha V, Jain S. et al. Effect of adjuvant homeopathy with usual care in management of thrombocytopenia due to dengue: a comparative cohort study. Homeopathy 2019; 108: 150-157
  • 10 de Souza Nunes LA. Contribution of homeopathy to the control of an outbreak of dengue in Macaé, Rio de Janeiro. Int J High Dilution Res 2008; 7: 186-192
  • 11 Jacobs J, Fernandez EA, Merizalde B, Avila-Montes GA, Crothers D. The use of homeopathic combination remedy for dengue fever symptoms: a pilot RCT in Honduras. Homeopathy 2007; 96: 22-26
  • 12 Saeed-ul-Hassan S, Tariq I, Khalid A, Karim S. Comparative clinical study on the effectiveness of homeopathic combination remedy with standard maintenance therapy for dengue fever. Trop J Pharm Res 2013; 12: 767-770
  • 13 Koraka P, Murgue B, Deparis X. et al. Elevated levels of total and dengue virus-specific immunoglobulin E in patients with varying disease severity. J Med Virol 2003; 70: 91-98
  • 14 King CA, Wegman AD, Endy TP. Mobilization and activation of the innate immune response to dengue virus. Front Cell Infect Microbiol 2020; 10: 574417
  • 15 Jeewandara C, Gomes L, Wickramasinghe N. et al. Platelet activating factor contributes to vascular leak in acute dengue infection. PLoS Negl Trop Dis 2015; 9: e0003459
  • 16 Cardosa J, Ooi MH, Tio PH. et al. Dengue virus serotype 2 from a sylvatic lineage isolated from a patient with dengue hemorrhagic fever. PLoS Negl Trop Dis 2009; 3: e423
  • 17 Shivanthan MC, Navinan MR, Constantine GR, Rajapakse S. Cardiac involvement in dengue infection. J Infect Dev Countries 2015; 9: 338-346
  • 18 Osnaya-Romero N, Perez-Guille MG, Andrade-García S. et al. Neurological complications and death in children with dengue virus infection: report of two cases. J Venom Anim Toxins Incl Trop Dis 2017; 23: 25
  • 19 Abdulla MC, Alungal J, Nagabhushan KN, Narayan R. Dengue fever presenting as epididymo-orchitis. Indian J Health Sci Biomed Res 2016; 9: 322-323
  • 20 Umakanth M. Dengue complicated with epididymo-orchitis, parotitis and rheumatoid like arthritis—case series. Sch J Med Case Rep 2018; 6: 62-65
  • 21 Wan SW, Wu-Hsieh BA, Lin YS, Chen WY, Huang Y, Anderson R. The monocyte-macrophage-mast cell axis in dengue pathogenesis. J Biomed Sci 2018; 25: 77
  • 22 Méndez-Domínguez N, Achach-Medina K, Morales-Gual YM, Gómez-Carro S. Dengue with unusual clinical features in an infant: Case report. Rev Chil Pediatr 2017; 88: 275-279
  • 23 Ulrich H, Pillat MM, Tárnok A. Dengue fever, COVID-19 (SARS-CoV-2), and antibody-dependent enhancement (ADE): a perspective. Cytometry A 2020; 97: 662-667
  • 24 Changal KH, Raina AH, Raina A. et al. Differentiating secondary from primary dengue using IgG to IgM ratio in early dengue: an observational hospital based clinico-serological study from North India. BMC Infect Dis 2016; 16: 715
  • 25 Míguez-Burbano MJ, Jaramillo CA, Palmer CJ. et al. Total immunoglobulin E levels and dengue infection on San Andrés Island, Colombia. Clin Diagn Lab Immunol 1999; 6: 624-626
  • 26 Tuchinda M, Dhorranintra B, Tuchinda P. Histamine content in 24-hour urine in patients with dengue haemorrhagic fever. Southeast Asian J Trop Med Public Health 1977; 8: 80-83
  • 27 Kien ND, El-Qushayri AE, Ahmed AM. et al. Association of allergic symptoms with dengue infection and severity: a systematic review and meta-analysis. Virol Sin 2020; 35: 83-92
  • 28 Vadas P, Perelman B, Liss G. Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis. J Allergy Clin Immunol 2013; 131: 144-149
  • 29 Vetter RS, Visscher PK. Bites and stings of medically important venomous arthropods. Int J Dermatol 1998; 37: 481-496
  • 30 Rathore AP, Mantri CK, Aman SA. et al. Dengue virus-elicited tryptase induces endothelial permeability and shock. J Clin Invest 2019; 129: 4180-4193
  • 31 Hahnemann S. Reine Arzneimittellehre. Vol. 3. 2nd ed.. Dresden: Arnoldische Buchhandlung; 1825
  • 32 Vetter RS, Visscher PK, Camazine S. Mass envenomations by honeybees and wasps. West J Med 1999; 170: 223-227
  • 33 Mingomataj EÇ, Bakiri AH. Episodic hemorrhage during honeybee venom anaphylaxis: potential mechanisms. J Investig Allergol Clin Immunol 2012; 22: 237-244
  • 34 Malavige GN, Ogg GS. Pathogenesis of vascular leak in dengue virus infection. Immunology 2017; 151: 261-269
  • 35 Barnard JH. Studies of 400 Hymenoptera sting deaths in the United States. J Allergy Clin Immunol 1973; 52: 259-264
  • 36 Reisman RE. Natural history of insect sting allergy: relationship of severity of symptoms of initial sting anaphylaxis to re-sting reactions. J Allergy Clin Immunol 1992; 90: 335-339
  • 37 Goddard J. Physician's Guide to Arthropods of Medical Importance. 6th ed.. Boca Raton, FL: CRC Press; 2013
  • 38 Morrison R. Desktop Guide to Keynotes and Confirmatory Symptoms. Albany, CA: Hahnemann Clinic Publishing; 1993
  • 39 Hering C. The Guiding Symptoms of Our Materia Medica. Vol. 1. Philadelphia: Estate of Constantine Hering; 1879
  • 40 Leeser O. Tierstoffe. 3rd ed.. In: Stübler M, Krug E. eds. Leesers Lehrbuch der Homöopathie. Vol. 5. Heidelberg, Germany: Karl F. Haug Verlag; 1987
  • 41 Metcalf JW. ed. Apis-mellifica. In: Homoeopathic Provings. New York: W. Radde; 1853: 184-203
  • 42 Manchanda RK. Dengue epidemic: What can we offer?. Indian J Res Homoeopathy 2015; 9: 137-140
  • 43 Hering C. The Guiding Symptoms of Our Materia Medica. Vol. 3. Philadelphia: Estate of Constantine Hering; 1881
  • 44 Imhäuser H. Homöopathie in der Kinderheilkunde: Aus der Praxis—für die Praxis. 7th ed.. Heidelberg, Germany: Karl F Haug Verlag; 1985
  • 45 Richardson-Boedler C. The use of patient-made blood isodes (nosodes) in infectious diseases including HIV-infection. Hom Int 1994; 8: 21-23
  • 46 Jacobs J. Homeopathic prevention and management of epidemic diseases. Homeopathy 2018; 107: 157-160
  • 47 Kasozi KI, Niedbała G, Alqarni M. et al. Bee venom—a potential complementary medicine candidate for SARS-CoV-2 infections. Front Public Health 2020; 8: 594458