Semin Respir Crit Care Med 2021; 42(05): 717-725
DOI: 10.1055/s-0041-1735150
Review Article

Survival Outcome of Sepsis in Recipients of Solid Organ Transplant

Diana F. Florescu
1  Transplant Infectious Diseases Program, University of Nebraska Medical Center, Omaha, Nebraska
2  Transplant Surgery Program, University of Nebraska Medical Center, Omaha, Nebraska
,
Andre C. Kalil
1  Transplant Infectious Diseases Program, University of Nebraska Medical Center, Omaha, Nebraska
› Author Affiliations

Abstract

Sepsis is a complex disease stemming from a dysregulated immune response toward an infectious agent. In transplantation, sepsis remains one of the leading causes of morbidity and mortality. Solid organ transplant recipients have impaired adaptive immunity due to immunosuppression required to prevent rejection. Immunosuppression has unintended consequences, such as increasing the risk of infections and sepsis. Due to its high morbidity and mortality, early detection of sepsis is paramount to start aggressive treatment. Several biomarkers or combination of biomarkers of sepsis have emerged in the last decade, but they are not dependable for early diagnosis or for outcome prognosis.



Publication History

Publication Date:
20 September 2021 (online)

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