The immune response to cancer is an ongoing area of interest and is the focus of newer
systemic agents. Liver-directed therapy has been the standard treatment for primary
and metastatic disease limited to the liver. It is increasingly being recognized that
these therapies may influence a broader systemic response and immune activation. The
clinical and translational data supporting this phenomenon are reviewed herein. The
findings and potential impact of the immune response to liver-directed therapies are
summarized in this article.
Keywords
liver-directed therapy - immune system - inflammatory response