Präventive körperliche Aktivität – „Bewege Dich und Dein Immunsystem – was bewirkt körperliche Aktivität?“

Längst ist bekannt, dass regelmäßige Bewegung vor chronischen Krankheiten schützt, das Gesamt-Mortalitätsrisiko senkt und ein enormes präventivmedizinisches Potenzial hat, vor allem auch im Hinblick auf die Genese von Tumorerkrankungen [1] . Gesunde Sportler haben nach neuesten Erkenntnissen sogar mehr entzündungshemmende, regulatorische T-Zellen im Blut als untrainierte Gesunde [2] . Allerdings nutzt gerade mal 1/3 der Europäer die Empfehlungen der WHO zur körperlichen Aktivität für den daraus resultierenden Überlebensvorteil, von dem sogar Aktive mit anderen Risikofaktoren profitieren. Dabei sinkt das allgemeine Mortalitätsrisiko um 14% und unsere Lebenserwartung steigt um 3 Jahre, wenn wir allein 15 min Sport am Tag betreiben. Ziel des folgenden Beitrages ist es, einen Überblick über den aktuellen Stand und die häufigsten Auswirkungen von körperlichem Training auf das Immunsystem zu geben.

Erstpublikation: Geburtshilfe Frauenheilkd 2016; 76: 23–25

• Literatur

• 1 Samitz G, Egger M, Zwahlen M. Domains of physical activity and all-cause mortality: systematic review and dose-response meta-analysis of cohort studies. Int J Epidemiol 2011; 40: 1382-1400
• 2 Weinhold M, Shimabukuro-Vornhagen A, Franke A, Theurich S, Wahl P, Hallek M et al. Physical exercise affects homeostasis of human regulatory T cells. J Allergy Clin Immunol 2015; – [im Druck]
• 3 WHO physical-activity-recommendations-18-64years. Webpage accessed 13. 12. 2015 http://www.who.int/dietphysicalactivity/physical-a
• 4 World Obesity Federation | World map of obesity. Webpage accessed 13. 12. 2015 http://www.worldobesity.org/resources/world-map-ob
• 5 Hoppeler H. Exercise-induced ultrastructural changes in skeletal muscle. Int J Sports Med 1986; 7: 187-204
• 6 Smith LL. Cytokine hypothesis of overtraining: a physiological adaptation to excessive stress?. Med Sci Sports Exerc 2000; 32: 317-331
• 7 Petersen AMW, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol 2005; 98: 1154-1162
• 8 Peake JM, Della Gatta P, Suzuki K, Nieman DC. Cytokine expression and secretion by skeletal muscle cells: regulatory mechanisms and exercise effects. Exerc. Immunol Rev 2015; 21: 8-25
• 9 Schmidt FM, Weschenfelder J, Sander C, Minkwitz J, Thormann J, Chittka T et al. Inflammatory cytokines in general and central obesity and modulating effects of physical activity. PLoS One 2015; 10: e0121971
• 10 Mishra SI, Scherer RW, Snyder C, Geigle PM, Berlanstein DR, Topaloglu O. Exercise interventions on health-related quality of life for people with cancer during active treatment. Cochrane Database Syst Rev 2012; (8) CD008465
• 11 Friedenreich CM, Cust AE. Physical activity and breast cancer risk: impact of timing, type and dose of activity and population subgroup effects. Br J Sports Med 2008; 42: 636-647
• 12 Laszlo R, Hartveg P, Laszlo S, Otto S, Prokopchuk D, Steinacker J. Physical Activity and Cancer. OA Sport Med 2014; 1-5
• 13 Fairey AS, Courneya KS, Field CJ, Mackey JR. Physical exercise and immune system function in cancer survivors: a comprehensive review and future directions. Cancer 2002; 94: 539-551
• 14 Woods JA, Evans JK, Wolters BW, Ceddia MA, McAuley E. Effects of maximal exercise on natural killer (NK) cell cytotoxicity and responsiveness to interferon-alpha in the young and old. J Gerontol A Biol Sci Med Sci 1998; 53: B430-437
• 15 Zimmer P, Baumann FT, Bloch W, Zopf EM, Schulz S, Latsch J et al. Impact of a half marathon on cellular immune system, pro-inflammatory cytokine levels, and recovery behavior of breast cancer patients in the aftercare compared to healthy controls. Eur J Haematol 2015; DOI: 10.1111/ejh.12561.
• 16 Fairey AS, Courneya KS, Field CJ, Bell GJ, Jones LW, Mackey JR. Randomized controlled trial of exercise and blood immune function in postmenopausal breast cancer survivors. J. Appl Physiol 2005; 98: 1534-1540
• 17 Goodwin PJ, Segal RJ, Vallis M, Ligibel JA, Pond GR, Robidoux A et al. Randomized trial of a telephone-based weight loss intervention in postmenopausal women with breast cancer receiving letrozole: the LISA trial. J Clin Oncol 2014; 32: 2231-2239
• 18 Verwey R, van der Weegen S, Spreeuwenberg M, Tange H, van der Weijden T, de Witte L. Process evaluation of physical activity counselling with and without the use of mobile technology: A mixed methods study. Int J Nurs Stud 2016; 53: 3-6
• 19 Verwey R, van der Weegen S, Tange H, Spreeuwenberg M, van der Weijden T, de Witte L. Get moving: the practice nurse is watching you! A case study of the user-centred design process and testing of a web-based coaching system to stimulate the physical activity of chronically ill patients in primary care. Inform Prim Care 2012; 20: 289-298
• 20 Verwey R, van der Weegen S, Spreeuwenberg M, Tange H, van der Weijden T, de Witte L. Upgrading physical activity counselling in primary care in the Netherlands. Health Promot Int 2014; DOI: 10.1093/heapro/dau107.
• 21 Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, Galvão DA, Pinto BM et al. American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc 2010; 42: 1409-1426
• 22 Hey-Mogensen M, Højlund K, Vind BF, Wang L, Dela F, Beck-Nielsen H et al. Effect of physical training on mitochondrial respiration and reactive oxygen species release in skeletal muscle in patients with obesity and type 2 diabetes. Diabetologia 2010; 53: 1976-1985
• 23 Teixeira de Lemos E, Pinto R, Oliveira J, Garrido P, Sereno J, Mascarenhas-Melo F et al. Differential effects of acute (extenuating) and chronic (training) exercise on inflammation and oxidative stress status in an animal model of type 2 diabetes mellitus. Mediators Inflamm 2011; DOI: 10.1155/2011/253061.
• 24 Kast K, Ditsch N, Kiechle MF. LIFESTYLE und erblicher Brustkrebs. Medizinische Genet 2015; 27: 237-243