Dtsch Med Wochenschr 2016; 141(11): 790-793
DOI: 10.1055/s-0042-107044
Klinischer Fortschritt
Pneumologie
© Georg Thieme Verlag KG Stuttgart · New York

Therapie des refraktären Asthmas mit Antikörpern

Treatment of refractory asthma with antibodies
Marek Lommatzsch
1   Abteilung für Pneumologie und Internistische Intensivmedizin, Zentrum für Innere Medizin, Universitätsklinikum Rostock
› Author Affiliations
Further Information

Publication History

Publication Date:
02 June 2016 (online)

Zusammenfassung

In den aktuellen Asthma-Therapie-Empfehlungen der GINA (global initiative for asthma) wird in der Therapie-Stufe 5 der zusätzliche Einsatz von Biologika empfohlen. Die vorliegende Übersichtsarbeit beschreibt die Wirkungen und das klinische Einsatzgebiet der Antikörper gegen Immunglobulin E, IgE (Omalizumab), Interleukin-5, IL-5 (Mepolizumab, Reslizumab) oder den IL-5-Rezeptor (Benralizumab). Desweiteren wird ein Ausblick auf potentiell zukünftig in der klinischen Praxis einsetzbare Antikörper für die Therapie des refraktären Asthma (z. B. Dupilumab) gegeben.

Abstract

Current guidelines of the global initiative for asthma (GINA) recommend the addition of biologics in step 5 of the stepwise asthma treatment approach. This review gives an overview on the effects and the clinical role of antibodies targeting immunoglobulin E, IgE (Omalizumab), Interleukin-5, IL-5 (Mepolizumab, Reslizumab) or the IL-5 receptor (Benralizumab). In addition, potential future treatment options of refractory asthma with antibodies (for instance Dupilumab) are discussed.

 
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