Zusammenfassung
Es wird über den Fall eines PSA-negativen und lokal fortgeschrittenen azinären Prostatakarzinoms
berichtet, das bei thyroid transcription factor-1 (TTF-1) Expression eine Metastase
eines bereits behandelten Bronchialkarzinoms imitierte. Unseres Wissens ist ein TTF-1
positiv azinäres Prostatakarzinom bisher nur ein Mal in der Literatur dokumentiert.
Die Bestimmung des Immunophänotyps des Karzinoms mit Napsin A, CK7 und CK20 in Kombination
mit der Beurteilung des gesamten Krankheitsverhaltens waren für die definitive Diagnose
eines primären Prostatakarzinoms entscheidend.
Abstract
A PSA-negative, advanced adenocarcinoma of the prostate is a rare finding. Expression
of thyroid transcription factor-1 (TTF-1) in the tumour in combination with a previous
medical history of lung adenocarcinoma could complicate the final diagnosis. To the
best of our knowledge, we present the second case of a TTF-1-positive, acinar adenocarcinoma
of the prostate.
We present the case of a 65-year-old male with surgically treated lung adenocarcinoma;
3 years later we diagnosed adenocarcinoma of the bladder and prostate. Although our
initial assumption was that the patient had metastatic lung carcinoma in the bladder
and prostate, a further immune histochemical analysis of the carcinoma with Napsin
A, CK7 and CK20, along with the evaluation of the clinical manifestations, led us
to the diagnosis of primary adenocarcinoma of the prostate.
Schlüsselwörter
PSA-negatives Prostatakarzinom - TTF-1 Expression - Bronchialkarzinom - Napsin A -
CK7 - CK20
Key words
PSA-negative adenocarcinoma of the prostate - TTF-1 expression - lung adenocarcinoma
- Napsin A - CK7 - CK20
