Acronychiabaueri Analogue Derivative-Loaded Ultradeformable Vesicles: Physicochemical Characterization and Potential Applications

Martina Di Francesco; Rosita Primavera; Serena Fiorito; Maria Chiara Cristiano; Vito Alessandro Taddeo; Francesco Epifano; Luisa Di Marzio; Salvatore Genovese; Christian Celia

doi:10.1055/s-0042-112225

Planta Medica, Table of Contents

Planta Med 2017; 83(05): 482-491
DOI: 10.1055/s-0042-112225

Formulation and Delivery Systems of Natural Products

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Acronychiabaueri Analogue Derivative-Loaded Ultradeformable Vesicles: Physicochemical Characterization and Potential Applications

Authors

Martina Di Francesco^*

¹Department of Health Sciences, University of Catanzaro “Magna Graecia”, Catanzaro, Italy
Rosita Primavera^*

²Department of Pharmacy, University of Chieti – Pescara “G. dʼAnnunzio”, Chieti, Italy
Serena Fiorito

²Department of Pharmacy, University of Chieti – Pescara “G. dʼAnnunzio”, Chieti, Italy
Maria Chiara Cristiano

¹Department of Health Sciences, University of Catanzaro “Magna Graecia”, Catanzaro, Italy
Vito Alessandro Taddeo

²Department of Pharmacy, University of Chieti – Pescara “G. dʼAnnunzio”, Chieti, Italy
Francesco Epifano

²Department of Pharmacy, University of Chieti – Pescara “G. dʼAnnunzio”, Chieti, Italy
Luisa Di Marzio

²Department of Pharmacy, University of Chieti – Pescara “G. dʼAnnunzio”, Chieti, Italy
Salvatore Genovese

²Department of Pharmacy, University of Chieti – Pescara “G. dʼAnnunzio”, Chieti, Italy
Christian Celia

²Department of Pharmacy, University of Chieti – Pescara “G. dʼAnnunzio”, Chieti, Italy

³Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, USA

Abstract

Elastic and ultradeformable liposomes were synthesized and physicochemically characterized to make suitable topical formulations for delivering the anti-inflammatory and anticancer compound 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans-propenoic acid. The average sizes of elastic and ultradeformable liposomes are below 300 nm, while the size distribution and Z-potential are below 0.3 and − 25 mV, respectively. The presence of 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans-propenoic acid does not affect the physicochemical parameters of nanovesicles. Elastic and ultradeformable liposomes show a zero order release kinetic and are stable at room temperature for a long time with or without 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans-propenoic acid. The ultradeformable liposomes are more deformable than elastic liposomes. These differences may depend on sodium cholate derivatives making nanoformulations. The 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans-propenoic acid-loaded elastic and ultradeformable liposomes can provide innovative nanotherapeutics-based natural compounds for the potential treatment of cutanous inflammation.

Key words

Acronychiabaueri species - elastic liposomes - ultradeformable liposomes - ethosomes - transfersomes - deformability study

Full Text

References

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