ZWR - Das Deutsche Zahnärzteblatt 2016; 125(09): 400-406
DOI: 10.1055/s-0042-115309
CME-Fortbildung
Georg Thieme Verlag KG Stuttgart · New York

Die Bedeutung von Antioxidantien im parodontalen Entzündungsgeschehen

H. Staudte
1   Markt Rettenbach/Jena
,
B. W. Sigusch
1   Markt Rettenbach/Jena
› Institutsangaben
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Publikationsverlauf

Publikationsdatum:
28. September 2016 (online)

Lernziele

Nach dem Durcharbeiten dieses Beitrags sollten Sie in der Lage sein,

  • die Rolle von ROS und Antioxidantien im Kontext der Parodontitis zu diskutieren,

  • Substanzen zu kennen, die eine antioxidative Wirkung im Rahmen einer ­unterstützenden Parodontitisbehandlung entfalten,

  • den Patienten Hinweise zur Optimierung der Antioxidantienaufnahme über die Ernährung geben zu können.

 
  • Literatur

  • 1 Varela-Lopez A, Quiles JL, Cordero M et al. Oxidative stress and dietary fat type in relation to periodontal disease. Antioxidants (Basal). 2015. 4. 322-344
  • 2 Guentsch A, Preshaw PM, Bremer-Streck S et al. Lipid peroxidation and antioxidant activity in saliva of periodontitis patients: effect of smoking and periodontal treatment. Clin Oral Investig 2008; 12: 345-352
  • 3 Shin MS, Shin HS, Ahn YB et al. Association between periodontitis and salivary 8-hydroxydeoxyguanosine among Korean rural adults. Community Dent Oral Epidemiol 2016; 44: 381-389
  • 4 Wagner A, Jahreis G. Nachweis von DNA-Schäden mittels Analyse von oxidierten Nukleosiden und deren Anwendung als Biomarker. Ernährungsumschau 2004; 5: 178-186
  • 5 Trivedi S, Lal N, Mahdi AA et al. Association of salivary lipid peroxidation levels, antioxidant enzymes, and chronic periodontitis. Int J Periodontics Restorative Dent 2015; 35: 14-19
  • 6 Baldrige CW, Gerhard RW. The extra respiration of phagocytosis. Am J Physiol 1933; 103: 235-236
  • 7 Kimura S, Yonemura T, Kaya H.. Increased oxidative product formation by peripheral blood polymorphonuclear leukocytes in human periodontal diseases. J Periodontal Res 1993; 28: 197-203
  • 8 Schraufstätter IU, Browne K, Harris A et al. Mechanisms of hypochlorite injury of target cells. J Clin Invest 1990; 85: 554-562
  • 9 Altman LC, Baker C, Fleckman P et al. Neutrophil-mediated damage to human gingival epithelial cells. J Periodontal Res 1992; 27: 70-79
  • 10 Padgett LE, Broniowska KA, Hansen PA et al. The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis. Ann N. Y. Acad Sci 2013; 1281: 16-35
  • 11 Damgaard C, Kantarci A, Holmstrup P et al. Porphyromonas gingivalis-induced production of reactive oxygen species, tumor necrosis factor-alpha, interleukine-6, CXCL8 and CCL2 by neutrophils from localized aggressive periodontitis and healthy donors: modulating actions of red blood cells and resolvin E1. J Periodontal Res 2016; (im Druck)
  • 12 Bostanci N, Belibasakis GN. Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen. FEMS Microbiol Lett 2012; 333: 1-9
  • 13 Sztukowska M, Bugno M, Potempa J et al. Role of rubrerythrin in the oxidative stress response of Porphyromonas gingivalis. Mol Microbiol 2002; 44: 479-488
  • 14 Smalley JW, Birss AJ, Silver J. The periodontal pathogen Porphysromonas gingivalis harnesses the chemistry of the γ-oxo bishaem of iron protoporphyrin IX to protect against hydrogen peroxide. FEMS Microbiol Lett 2000; 183: 159-164
  • 15 Choi CH, Spooner R, DeGuzman J et al. Porphyromonas gingivalis-nucleoside-diphosphate-kinase inhibits ATP-induces reactive-oxygen-species via P2×7 receptor/NADPH-oxidase signalling and contributes to persistence. Cell Microbiol 2013; 15: 961-976
  • 16 Sculley DV, Langley-Evans SC. Salivary antioxidants and periodontal disease status. Proc Nutr Soc 2002; 61: 137-143
  • 17 Nagler RM, Klein I, Zarzhevsky N et al. Characterization of the differentiated antioxidant profile of human saliva. Free Radic Biol Med 2002; 32: 268-277
  • 18 Wu Y, Shu R, Luo LJ et al. Initial comparison of proteomic profiles of whole unstimulated saliva obtained from generalized aggressive periodontitis patients and healthy control subjects. J Periodontal Res 2009; 44: 636-644
  • 19 Jenifer HD, Bhola S, Kalburgi V et al. The influence of cigarette smoking on blood and salivary super oxide dismutase enzyme levels among smokers and non-smokers – a cross selectional study. J Tradit Complement Med 2015; 5: 100-105
  • 20 Linden GJ, McClean KM, Woodside JV et al. Antioxidants and periodontitis in 60–70-year-old men. J Clin Periodontol 2009; 36: 843-849
  • 21 Pendyala G, Thomas B, Kumari S. The challange of antioxidants to free radicals in periodontitis. J Indian Soc Periodontol 2008; 12: 79-83
  • 22 Brock GR, Butterworth CJ, Matthews JB et al. Local and systemic antioxidant capacity in periodontitis and health. J Clin Periodontol 2004; 31: 515-521
  • 23 Chapple IL, Matthews JB. The role of reactive oxygen and antioxidant species in periodontal tissue destruction. Periodontology 2000 2007; 43: 160-232
  • 24 Staudte H, Sigusch BW, Glockmann E. Grapefruit consumption improves vitamin C status in periodontitis patients. Br Dent J 2005; 199: 213-217
  • 25 Kuzmanova D, Jansen ID, Schoenmaker T et al. Vitamin C in plasma and leucocytes in relation to periodontitis. J Clin Periodontol 2012; 39: 905-912
  • 26 Amaliya Timmerman MF, Abbas F. et al. Java project on periodontal diseases: the relationship between vitamin C and the severity of periodontitis. J Clin Periodontol 2007; 34: 299-304
  • 27 Meyle J, Schulte W, Dopfer R et al. Functional studies of neutrophilic granulocytes in periodontitis and mouth mucosal diseases. Dtsch Zahnärztl Z 1984; 39: 388-395
  • 28 Vissers MC, Wilkie RP. Ascorbate deficiency results in impaired neutrophil apoptosis and clearance and is associated with up-regulation of hypoxia-inducible factor 1α. J Leukoc Biol 2007; 81: 1236-1244
  • 29 Wang Y, Russo TA, Kwon O et al. Ascorbate recycling in human neutrophils: induction by bacteria. Proc Natl Acad Sci USA 1997; 94: 13816-13819
  • 30 Fisher BJ, Seropian IM, Kraskauskas D et al. Ascorbic acid attenuates lipopolysaccharide-induced acute lung injury. Crit Care Med 2011; 39: 1454-1460
  • 31 Goldschmidt MC. Reduced bactericidal activity in neutrophils from scorbutic animals and the effect of ascorbic acid on these target bacteria in vivo and in vitro. Am J Clin Nutr 1991; 54: 1214-1220
  • 32 Staudte H, Güntsch A, Völpel A et al. Vitamin C attenuates the cytotoxic effects of Porphyromonas gingivalis on human gingival fibroblasts. Arch Oral Biol 2010; 55: 40-45
  • 33 Munoz CA, Kiger RD, Stephens JA et al. Effects of a nutritional supplement on periodontal status. Compend Contin Educ Dent 2001; 22: 425-428
  • 34 Battino M, Bompadre S, Politi A et al. Antioxidant status (CoQ10 and Vitamin E levels) and immunohistochemical analysis of soft tissues in periodontal diseases. Biofactors 2005; 25: 213-217
  • 35 Zong G, Scott AE, Griffiths HR et al. Serum α-Tocopherol has a nonlinear inverse association with periodontitis among US adults. J Nutr 2015; 145: 893-899
  • 36 Cohen ME, Meyer DM. Effect of dietary vitamin E supplementation and rotational stress on alveolar bone loss in rice rats. Arch Oral Biol 1993; 38: 601-606
  • 37 Derradija A, Alanazi H, Park HJ et al. α-tocopherol decreases interleukin-1β and -6 and increases human β-defensin-1 and -2 secretion in human gingival fibroblasts stimulated with Porphyromonas gingivalis lipopolysaccharide. J Periodontal Res 2016; 51: 295-303
  • 38 Dodington DW, Fritz PC, Sullivan PJ et al. Higher intakes of fruits and vegetables, β-carotene, vitamin C, α-tocopherol, EPA and DHA are positively associated with periodontal healing after nonsurgical periodontal therapy in nonsmokers but not in smokers. J Nutr 2015; 145: 2512-2519
  • 39 Iwamoto Y, Nakamura R, Folkers K et al. Study of periodontal disease and coenzyme Q. Res Commun Chem Pathol Pharmacol 1975; 11: 265-271
  • 40 Hansen IL, Iwamoto Y, Kishi T et al. Bioenergetics in clinical medicine. IX. Gingival and leucocytic deficiencies of coenzyme Q10 in patients with periodontal disease. Res Commun Chem Pathol Pharmacol 1976; 14: 729-738
  • 41 Hanioka T, Tanaka M, Ojima M et al. Effect of topical application of coenzyme Q10 on adult periodontitis. Mol Aspects Med 1994; 15: S241-S248
  • 42 Manthena S, Rao MV, Penubolu LP et al. Effectiveness of CoQ10 oral supplements as an adjunct to scaling and root planning in improving periodontal health. J Clin Diagn Res 2015; 9: 26-28
  • 43 Varela-Lopez A, Bullon P, Battino M et al. Coenzyme Q protects against age-related alveolar bone loss associated to n-6 polyunsaturated fatty acids rich-diets by modulating mitochondrial mechanisms. J Gerontol A Biol Sci Med Sci 2016; 71: 593-600
  • 44 Sale ST, Parvez H, Yeltiwar RK et al. A comperative evaluation of topical and intrasulcular application of coenzyme Q10 (Perio QTM) gel in chronic periodontitis patients: a clinical study. J Indian Soc Periodontol 2014; 18: 461-465
  • 45 Burgerstein U. Handbuch Nährstoffe. 12. Auflage Stuttgart: Trias; 2012
  • 46 Akman S, Canakci V, Kara A et al. Therapeutic effects of alpha lipoic acid and vitamin C on alveolar bone resorption after experimental periodontitis in rats: a biochemical, histochemical, and stereologic study. J Periodontol 2013; 84: 666-674
  • 47 Lakhtin LuV. Comperative evaluation of short- and long-term treatment of periodontitis with alpha-lipoic acid. Georgian Med News 2013; 218: 19-22
  • 48 DiSilvestro RA, DiSilvestro DJ. Pomegranate extract mouth rinsing effects on saliva measures relevant to gingivitis risk. Phytother Res 2009; 23: 1123-1127
  • 49 Feghali K, Feldman M, La VD et al. Cranberry proanthocyanidins: natural weapons against periodontal diseases. J Agric Food Chem 2012; 60: 5728-5735
  • 50 Zare Javid A, Seal CJ, Heasman P. Impact of a customised dietary intervention on antioxidant status, dietary intakes and periodontal indices in patients with adult periodontitis. J Hum Nutr Diet 2014; 27: 523-532