Int J Sports Med 2017; 38(1): 76-80
DOI: 10.1055/s-0042-117113
Genetics & Molecular Biology
© Georg Thieme Verlag KG Stuttgart · New York

The Association Between MCT1 T1470A Polymorphism and Power-Oriented Athletic Performance

N. Kikuchi1, N. Fuku2, R. Matsumoto3, S. Matsumoto1, H. Murakami4, M. Miyachi4, K. Nakazato5
  • 1Faculty of Sport Science, Nippon Sport Science University, Tokyo, Japan
  • 2Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan
  • 3Graduate School of Medicine, Gunma University, Maebashi-city, Japan
  • 4Department of Health Promotion and Exercise, National Institute of Health and Nutrition, NIBIOHN, Tokyo, Japan
  • 5Faculty of Medical Science, Nippon Sport Science University, Tokyo, Japan
Further Information

Publication History

accepted after revision 30 August 2016

Publication Date:
03 November 2016 (eFirst)


The purpose of this study was to investigate the effects of the MCT1 T1470A polymorphism (rs1049434) on power-oriented performance and lactate concentration during or after cycling sprints in Japanese wrestlers. Participants (199 wrestlers and 649 controls) were genotyped for the MCT1 T1470A genotype (rs1049434) using the TaqMan® Assay. All wrestlers were international (n=77) or national (n=122) level athletes. Among them, 46 wrestlers performed 2 anaerobic performance tests, a 30-s Wingate Anaerobic test (WAnT) and a series of 10 maximal effort 10-s sprints on a cycle ergometer. Blood lactate levels were measured before, during, and after the tests. In the A-allele recessive model (AA vs. TA+TT), the frequency of the AA genotype was significantly higher in all wrestlers than in controls (p=0.037). Wrestlers with AA genotype had lower blood lactate concentrations than those with TA+TT genotype at 10 min after the WAnT and following the 5th and the final set of repeated cycling sprints (p<0.05). The AA genotype of the MCT1 T1470A polymorphism is over-represented in wrestlers compared with controls and is associated with lower blood lactate concentrations after 30-s WAnT and during intermittent sprint tests in Japanese wrestlers.

Supplementary Material