PPAR-γ Agonists for the Treatment of Major Depression: A Review

R. Colle; D. de Larminat; S. Rotenberg; F. Hozer; P. Hardy; C. Verstuyft; B. Fève; E. Corruble

doi:10.1055/s-0042-120120

Pharmacopsychiatry, Inhaltsverzeichnis

Pharmacopsychiatry 2017; 50(02): 49-55
DOI: 10.1055/s-0042-120120

Review

PPAR-γ Agonists for the Treatment of Major Depression: A Review

Authors

R. Colle^*

¹University Paris-Sud, Le Kremlin Bicêtre, France

²INSERM, UMRS 1178, Le Kremlin Bicêtre, France

³Hôpital Bicêtre, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France

⁴Département de Psychiatrie, Le Kremlin Bicêtre, France
D. de Larminat^*

¹University Paris-Sud, Le Kremlin Bicêtre, France

²INSERM, UMRS 1178, Le Kremlin Bicêtre, France

³Hôpital Bicêtre, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France

⁴Département de Psychiatrie, Le Kremlin Bicêtre, France
S. Rotenberg

¹University Paris-Sud, Le Kremlin Bicêtre, France

²INSERM, UMRS 1178, Le Kremlin Bicêtre, France

³Hôpital Bicêtre, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France

⁴Département de Psychiatrie, Le Kremlin Bicêtre, France
F. Hozer

¹University Paris-Sud, Le Kremlin Bicêtre, France

²INSERM, UMRS 1178, Le Kremlin Bicêtre, France

³Hôpital Bicêtre, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France

⁴Département de Psychiatrie, Le Kremlin Bicêtre, France
P. Hardy

¹University Paris-Sud, Le Kremlin Bicêtre, France

²INSERM, UMRS 1178, Le Kremlin Bicêtre, France

³Hôpital Bicêtre, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France

⁴Département de Psychiatrie, Le Kremlin Bicêtre, France
C. Verstuyft

¹University Paris-Sud, Le Kremlin Bicêtre, France

³Hôpital Bicêtre, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France

⁵INSERM UMR_S1184, Centre IMVA

⁶Service de Génétique moléculaire, Pharmacogénétique et Hormonologie
B. Fève^*

⁷Sorbonne Universités, Université Pierre et Marie Curie, Centre de Recherche Saint-Antoine, INSERM UMR_S938, Paris, France

⁸Institut Hospitalo-Universitaire ICAN, Paris, France

⁹Service d’Endocrinologie, Assistance Publique des Hôpitaux de Paris, Hôpital Saint-Antoine, Paris, France
E. Corruble^*

¹University Paris-Sud, Le Kremlin Bicêtre, France

²INSERM, UMRS 1178, Le Kremlin Bicêtre, France

³Hôpital Bicêtre, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France

⁴Département de Psychiatrie, Le Kremlin Bicêtre, France

Abstract

Introduction: Selective agonists of the nuclear transcription factor peroxisome proliferator-activated receptor-gamma (PPAR-γ) are used for the treatment of type 2 diabetes. We reviewed their efficacy and safety for the treatment of major depression and the association of their potential antidepressant effects with changes in biomarkers of metabolism and inflammation.

Methods: From 8 studies, 4 open-label trials, and 4 randomized controlled trials (RCT) (3 vs. placebo and 1 vs. metformin), 448 patients with major depression were included, of which 209 patients received PPAR-γ agonists (pioglitazone or rosiglitazone) for 6–12 weeks, either alone or in add-on therapy to conventional treatments.

Results: PPAR-γ agonists have antidepressant effects in the 4 open-label studies and in 3 out of 4 RCT. No major adverse event was reported. Improvement in depression scores was associated with improvement in 3 biomarkers of insulin resistance (homeostatic model assessment [HOMA-IR], oral glucose tolerance test, and fasting plasma glucose) and 1 biomarker of inflammation (interleukin-6) among 21 biomarkers studied.

Conclusion: PPAR-γ agonists may have antidepressant properties, which need to be assessed in further studies of major depressive episodes.

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Referenzen

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