The Clinical Characteristics of Obese Patients with Acanthosis Nigricans and Its Independent Risk Factors

Yueye Huang; Jiaqi Chen; Xingchun Wang; Yan Li; Shezhen Yang; Shen Qu

doi:10.1055/s-0042-123035

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2017; 125(03): 191-195
DOI: 10.1055/s-0042-123035

Article

The Clinical Characteristics of Obese Patients with Acanthosis Nigricans and Its Independent Risk Factors

Authors

Yueye Huang

¹Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China
Jiaqi Chen

¹Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China
Xingchun Wang

¹Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China
Yan Li

¹Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China
Shezhen Yang

²Department of Endocrinology, Haimen People’s Hospital, Jiangsu, China
Shen Qu

¹Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China

Abstract

Objective: This study aimed to investigate the clinical characteristics and risk factors for acanthosis nigricans (AN) in obese patients.

Methods: 80 obese patients without AN (OB group) and 128 obese patients with AN (AN group) were included in this study. Clinical data for each patients were collected. Serum levels of leptin were measured by ELISA.

Results: Body mass index (BMI), uric acid (UA) levels, fasting insulin, and HOMA-IR were higher in AN than OB (P<0.05). The levels of leptin were significantly higher in AN than OB (P<0.001) after adjustment for BMI and gender. In male patients, AN showed lower serum levels of testosterone than OB (P<0.001). Multiple Logistic-regression analysis demonstrated that UA (OR 4.627, 95%CI 2.443–8.762, P<0.001) and Leptin (OR 4.098, 95%CI 1.237–13.581, P=0.021) were independent risk factors for AN. In addition, low testosterone level was an independent risk factor for AN in male obese patients (OR 39.062, 95%CI 5.523–283.808, P<0.001).

Conclusions: AN is associated with more severe hyperinsulinemia and hyperuricemia in obese patients, as well as lower serum testosterone levels in male patients. UA and Leptin were independent risk factors for AN in obese patients. Low testosterone may be a valuable predictor of AN in male obese patients.

Key words

obesity - acanthosis nigricans - insulin resistance - leptin - testosterone

Full Text

References

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