Diabetes Mellitus and Bone Metabolism

Christian Kasperk; Carmen Georgescu; Peter Nawroth

doi:10.1055/s-0042-123036

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2017; 125(04): 213-217
DOI: 10.1055/s-0042-123036

Review

Diabetes Mellitus and Bone Metabolism

Authors

Christian Kasperk

¹Medizinische Universitätsklinik Heidelberg, Abteilung Innere Medizin I und Klinische Chemie, INF, Heidelberg
Carmen Georgescu

⁴Department of Endocrinology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Rumänien
Peter Nawroth

¹Medizinische Universitätsklinik Heidelberg, Abteilung Innere Medizin I und Klinische Chemie, INF, Heidelberg

²Helmholtz Zentrum München, German Research Center for Environmental Health, Institute for Diabetes and Cancer, Ingolstädter Landstraße, Neuherberg

³Deutsches Diabetes Zentrum (DDZ), an der Heinrich Heine Universität Düsseldorf, Auf’m Hennekamp, Düseldorf

Abstract

Diabetes mellitus and bone metabolism affect mesenchymal tissues and have numerous epidemiological and pathophysiological associations in common. Diabetes mellitus affects bone metabolism and increases fracture risk. The pathophysiological mechanims how type 1 and type 2 diabetes impair bone metabolism and bone strength may differ which is outlined in this review. Direct metabolic effects in additon to centrally controlled endocrine loops exert suppressive effects on bone formation and may also stimulate bone Resorption. Decreased bone formation in combination with increased bone resorption strongly increases fracture risk.

Key words

bone - fracture risk - energy metabolism - Diabetes<Autoimmunity - osteoporosis

Full Text

References

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