CC BY 4.0 · Aorta (Stamford) 2022; 10(01): 020-025
DOI: 10.1055/s-0042-1742699
Original Research Article

New Measures, Old Conclusions: Obesity Does Not Worsen Outcomes after Elective Abdominal Aortic Aneurysm Repair

1   Leeds Vascular Institute, Leeds General Infirmary, Leeds, West Yorkshire, United Kingdom
2   Leeds Teaching Hospitals NHS Trust, St James' University Hospital, Leeds, West Yorkshire, United Kingdom
,
2   Leeds Teaching Hospitals NHS Trust, St James' University Hospital, Leeds, West Yorkshire, United Kingdom
,
Mohammed A. Waduud
1   Leeds Vascular Institute, Leeds General Infirmary, Leeds, West Yorkshire, United Kingdom
,
Keleabetswe Pabale
1   Leeds Vascular Institute, Leeds General Infirmary, Leeds, West Yorkshire, United Kingdom
,
Benjamin Wood
2   Leeds Teaching Hospitals NHS Trust, St James' University Hospital, Leeds, West Yorkshire, United Kingdom
,
Marc Bailey
1   Leeds Vascular Institute, Leeds General Infirmary, Leeds, West Yorkshire, United Kingdom
3   Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom
,
Julian A. Scott
1   Leeds Vascular Institute, Leeds General Infirmary, Leeds, West Yorkshire, United Kingdom
2   Leeds Teaching Hospitals NHS Trust, St James' University Hospital, Leeds, West Yorkshire, United Kingdom
› Author Affiliations
Funding None.

Abstract

Background The “obesity paradox,” whereby the body mass index (BMI) mortality curve is “U-shaped,” is a well-studied phenomenon in vascular surgery. However, there has been an overreliance on BMI as the measure of obesity, which has shown to poorly correlate with clinical outcomes. Robust measures such as waist-hip ratio (WHR) have been suggested as a more accurate marker reflecting central obesity.

Objectives The objectives of this study were to evaluate the correlation between BMI and WHR on postoperative morbidity and mortality after elective abdominal aortic aneurysm (AAA) repair.

Methods Data were collected from the Leeds Vascular Institute between January 2006 and December 2016. The primary outcome was mortality and secondary outcomes included length of stay (LOS) and all-cause readmission. Binary logistic regression, linear regression, and correlation analysis were used to identify associations between BMI and WHR in relation to outcome measures.

Results After exclusions, 432 elective AAA repairs (281 open surgical repair [OSR] and 151 endovascular aneurysm repairs [EVARs]) were identified to be eligible for the study. The combined 30-day and 4-year mortality was 1.2 and 20.1%, respectively. The 30-day readmission rate was 3.9% and the average LOS was 7.33 (standard deviation 18.5) days. BMI data was recorded for 275 patients (63.7%) and WHR for 355 patients (82.2%). Logistic regression analysis highlighted no association between BMI and WHR with mortality, readmission, or LOS following OSR or EVAR.

Conclusion The results of this study suggest patients should not be denied treatment for AAA based on obesity alone.



Publication History

Received: 21 January 2021

Accepted: 30 August 2021

Article published online:
31 May 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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  • References

  • 1 Galyfos G, Geropapas GI, Kerasidis S, Sianou A, Sigala F, Filis K. The effect of body mass index on major outcomes after vascular surgery. J Vasc Surg 2017; 65 (04) 1193-1207
  • 2 Miller MS, Kang M, Cornwall JC. et al. The impact of body mass index on perioperative and postoperative outcomes for endovascular abdominal aneurysm repair. Ann Vasc Surg 2020; 62: 183-190.e1
  • 3 Davenport DL, Xenos ES, Hosokawa P, Radford J, Henderson WG, Endean ED. The influence of body mass index obesity status on vascular surgery 30-day morbidity and mortality. J Vasc Surg 2009; 49 (01) 140-147 , 147.e1, discussion 147
  • 4 Mousa AY, Bozzay J, Broce M. et al. Novel risk score model for prediction of survival following elective endovascular abdominal aortic aneurysm repair. Vasc Endovascular Surg 2016; 50 (04) 261-269
  • 5 De Schutter A, Lavie CJ, Milani RV. The impact of obesity on risk factors and prevalence and prognosis of coronary heart disease-the obesity paradox. Prog Cardiovasc Dis 2014; 56 (04) 401-408
  • 6 Lavie CJ, De Schutter A, Parto P. et al. Obesity and prevalence of cardiovascular diseases and prognosis-the obesity paradox updated. Prog Cardiovasc Dis 2016; 58 (05) 537-547
  • 7 Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath Jr CW. Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med 1999; 341 (15) 1097-1105
  • 8 Smeili LAA, Lotufo PA. Incidence and predictors of cardiovascular complications and death after vascular surgery. Arq Bras Cardiol 2015; 105 (05) 510-518
  • 9 Brovman EY, Steen TL, Urman RD. et al. Obesity: preventing and managing the global epidemic. J Vasc Surg 2013; 31 (02) 2275-2279
  • 10 Kennedy NA, Flynn LM, Berg RM, Lorelli DR, Rama K, Rizk Y. The evaluation of morbidity and mortality in abdominal aortic aneurysm repair patients as related to body mass index. Am J Surg 2010; 199 (03) 369-371 , discussion 371
  • 11 Giles KA, Wyers MC, Pomposelli FB, Hamdan AD, Ching YA, Schermerhorn ML. The impact of body mass index on perioperative outcomes of open and endovascular abdominal aortic aneurysm repair from the National Surgical Quality Improvement Program, 2005-2007. J Vasc Surg 2010; 52 (06) 1471-1477
  • 12 Hamer M, O'Donovan G, Stensel D, Stamatakis E. Normal-weight central obesity and risk for mortality. Ann Intern Med 2017; 166 (12) 917-918
  • 13 Pischon T, Boeing H, Hoffmann K. et al. General and abdominal adiposity and risk of death in Europe. N Engl J Med 2008; 359 (20) 2105-2120
  • 14 World Health Organization. Obesity: preventing and managing the global epidemic. Tech Rep Ser (World Health Organ) 2000; 1-268
  • 15 Pa CK. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study). Universitas (Stuttg) 2010; 37 (06) 111-125
  • 16 Kartheuser AH, Leonard DF, Penninckx F. et al; Waist Circumference Study Group. Waist circumference and waist/hip ratio are better predictive risk factors for mortality and morbidity after colorectal surgery than body mass index and body surface area. Ann Surg 2013; 258 (05) 722-730
  • 17 Stackelberg O, Björck M, Sadr-Azodi O, Larsson SC, Orsini N, Wolk A. Obesity and abdominal aortic aneurysm. Br J Surg 2013; 100 (03) 360-366
  • 18 Dripps RD. New classification of physical status. Anesthesiology 1963; 24: 111
  • 19 Fowkes FGR, Greenhalgh RM, Powell JT. et al. Length of hospital stay following elective abdominal aortic aneurysm repair. U.K. Small Aneurysm Trial Participants. Eur J Vasc Endovasc Surg 1998; 16 (03) 185-191
  • 20 Dunn OJ. Multiple comparisons among means. J Am Stat Assoc 1961; 56 (293) 52
  • 21 Johnson III ON, Sidawy AN, Scanlon JM. et al. Impact of obesity on outcomes after open surgical and endovascular abdominal aortic aneurysm repair. J Am Coll Surg 2010; 210 (02) 166-177
  • 22 Jonker FHW, Schlösser FJV, Dewan M. et al. Influence of obesity on in-hospital and midterm outcomes after endovascular repair of abdominal aortic aneurysm. J Endovasc Ther 2009; 16 (03) 302-309
  • 23 Saratzis A, Saedon M, Melas N, Kitas GD, Mahmood A. Obesity as an independent predictor of outcome after endovascular abdominal aortic aneurysm repair. Ann Vasc Surg 2014; 28 (04) 816-822
  • 24 Salomon du Mont L, Mauny F, Chrétien N. et al. Obesity is not an independent factor for adverse outcome after abdominal aortic aneurysm repair. Ann Vasc Surg 2016; 33: 67-74
  • 25 Locham S, Rizwan M, Dakour-Aridi H, Faateh M, Nejim B, Malas M. Outcomes after elective abdominal aortic aneurysm repair in obese versus nonobese patients. J Vasc Surg 2018; 68 (06) 1696-1705
  • 26 Jonker FHW, Schlösser FJV, Dewan M. et al. Abdominal aortic aneurysm repair in obese patients: improved outcome after endovascular treatment compared with open surgery. Vasc Endovascular Surg 2010; 44 (02) 105-109