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Semin Thromb Hemost 2022; 48(03): 274-276
DOI: 10.1055/s-0042-1742737
Preface

Hemostasis and Neuroscience—Hemostasis and Fibrinolysis Involved in Brain Pathology and Brain Disorders

Christine Lodberg Hvas
1   Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark
2   Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
,
Hau C. Kwaan
3   Division of Hematology/Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
,
Anne-Mette Hvas
2   Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
4   Thrombosis and Hemostasis Research Unit, Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
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Vascular occlusive events and hemorrhage in the brain affect thousands of lives across the globe every day. Thrombosis and hemostasis impact outcome after cerebrovascular disease, and its prevention and treatment include manipulation of systemic coagulation factors. The brain also has its own unique system for regulation of hemostasis.[1] Local thrombin generation in the brain affects the prognosis in epileptic seizures and multiple sclerosis,[2] while tissue plasminogen activator (tPa) affects blood–brain barrier permeability and is involved in Alzheimer's disease pathology.[3] This issue of Seminars of Thrombosis and Hemostasis will, in three parts, shed light on mechanisms and potential treatment targets in vascular occlusive events, in intracerebral and subarachnoid hemorrhage, and finally in the role of platelets and endogenous tPa in Alzheimer's and Parkinson's diseases.



Publication History

Article published online:
12 April 2022

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  • References

  • 1 Fisher MJ. Brain regulation of thrombosis and hemostasis: from theory to practice. Stroke 2013; 44 (11) 3275-3285
    CrossrefPubMedGoogle Scholar
  • 2 Stein ES BS, Gofrit SG, Altman K, Weinberg N, Maggio N. Neurocoagulation from a mechanistic point of view in the central nervous system. Semin Thromb Hemost 2022; 48 (03) 277-287
    Article in Thieme ConnectPubMedGoogle Scholar
  • 3 Stevenson TK, Moore SJ, Murphy GG, Lawrence DA. Tissue plasminogen activator in central nervous system physiology and pathology: from synaptic plasticity to Alzheimer's disease. Semin Thromb Hemost 2022; 48 (03) 288-300
    Article in Thieme ConnectPubMedGoogle Scholar
  • 4 Fletcher-Sandersjöö A, Tatter C, Tjerkaski J, Bartek Jr J, Svensson M, Thelin EP, Bo-Michael Bellander BM. Clinical significance of vascular occlusive events following moderate-to-severe traumatic brain injury: an observational cohort study. Semin Thromb Hemost 2022; 48 (03) 301-308
    Article in Thieme ConnectPubMedGoogle Scholar
  • 5 Aamodt AH, Skattør ST. Cerebral venous thrombosis. Semin Thromb Hemost 2022; 48 (03) 309-317
    Article in Thieme ConnectPubMedGoogle Scholar
  • 6 Lippi G, Favaloro EJ. Cerebral venous thrombosis developing after COVID-19 vaccination: VITT, VATT, TTS, and more. Semin Thromb Hemost 2022; 48 (01) 8-14
    Article in Thieme ConnectPubMedGoogle Scholar
  • 7 Panagopoulos D, Karydakis P, Noutsos G, Themistocleous M. Venous thromboembolism risk and thromboprophylaxis in pediatric neurosurgery and spinal injury: current trends and literature review. Semin Thromb Hemost 2022; 48 (03) 318-322
    Article in Thieme ConnectPubMedGoogle Scholar
  • 8 Winther-Larsen A, Sandfeld-Paulsen B, Hvas AM. New insights in coagulation and fibrinolysis in patients with primary brain cancer: a systematic review. Semin Thromb Hemost 2022; 48 (03) 323-337
    Article in Thieme ConnectPubMedGoogle Scholar
  • 9 Macdonald RL, Schweizer TA. Spontaneous subarachnoid haemorrhage. Lancet 2017; 389 (10069): 655-666
    CrossrefPubMedGoogle Scholar
  • 10 Kwaan HC. Nonhematologic and hematologic factors in spontaneous intracerebral hemorrhage. Semin Thromb Hemost 2022; 48 (03) 338-343
    Article in Thieme ConnectPubMedGoogle Scholar
  • 11 Dorgalaleh AFY, Haeri K, Ghanbari OB, Ahmadi A. Risk and management of intracerebral hemorrhage in patients with bleeding disorders. Semin Thromb Hemost 2022; 48 (03) 344-355
    Article in Thieme ConnectPubMedGoogle Scholar
  • 12 Hvas CL, Hvas AM. Hemostasis and fibrinolysis following aneurysmal subarachnoid hemorrhage: a systematic review on additional knowledge from dynamic assays and potential treatment targets. Semin Thromb Hemost 2022; 48 (03) 356-381
    Article in Thieme ConnectPubMedGoogle Scholar
  • 13 Page MJ, Pretorius E. Platelet behavior contributes to neuropathologies: a focus on Alzheimer's and Parkinson's disease. Semin Thromb Hemost 2022; 48 (03) 382-404
    Article in Thieme ConnectPubMedGoogle Scholar